Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2743392..2744085 Replicon chromosome
Accession NZ_CP035822
Organism Escherichia coli strain WS4437A-1

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag EXA06_RS13365 Protein ID WP_000415584.1
Coordinates 2743789..2744085 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag EXA06_RS13360 Protein ID WP_000650107.1
Coordinates 2743392..2743787 (-) Length 132 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXA06_RS13350 (2739256) 2739256..2741514 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
EXA06_RS13355 (2741652) 2741652..2743259 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
EXA06_RS13360 (2743392) 2743392..2743787 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
EXA06_RS13365 (2743789) 2743789..2744085 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
EXA06_RS13370 (2744290) 2744290..2744772 - 483 WP_001413984.1 GyrI-like domain-containing protein -
EXA06_RS13375 (2744825) 2744825..2745217 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
EXA06_RS13380 (2745368) 2745368..2746027 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
EXA06_RS13385 (2746024) 2746024..2747373 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
EXA06_RS13390 (2747419) 2747419..2747751 - 333 WP_000917684.1 DUF2645 family protein -
EXA06_RS13395 (2748070) 2748070..2748651 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
EXA06_RS13400 (2748682) 2748682..2748996 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-97)

Antitoxin

(3-47)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T118637 WP_000415584.1 NZ_CP035822:c2744085-2743789 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T118637 NZ_CP035822:c2744085-2743789 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT118637 WP_000650107.1 NZ_CP035822:c2743787-2743392 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT118637 NZ_CP035822:c2743787-2743392 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 3HI2


Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References