Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-Phd
Location 3594551..3595053 Replicon chromosome
Accession NZ_CP035807
Organism Thiospirochaeta perfilievii strain P

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag EW093_RS16675 Protein ID WP_149569486.1
Coordinates 3594551..3594811 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag EW093_RS16680 Protein ID WP_149569487.1
Coordinates 3594811..3595053 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW093_RS16645 3590115..3590861 + 747 WP_149569481.1 site-specific integrase -
EW093_RS16650 3590831..3591001 + 171 WP_149569641.1 tyrosine-type recombinase/integrase -
EW093_RS16655 3591003..3592106 + 1104 WP_149569482.1 transposase -
EW093_RS16660 3592513..3593118 - 606 WP_149569483.1 hypothetical protein -
EW093_RS16665 3593119..3593496 - 378 WP_149569484.1 hypothetical protein -
EW093_RS16670 3593490..3594194 - 705 WP_149569485.1 hypothetical protein -
EW093_RS16675 3594551..3594811 - 261 WP_149569486.1 Txe/YoeB family addiction module toxin Toxin
EW093_RS16680 3594811..3595053 - 243 WP_149569487.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EW093_RS16685 3595762..3596154 - 393 WP_149569488.1 hypothetical protein -
EW093_RS16690 3596213..3596518 + 306 WP_149566821.1 hypothetical protein -
EW093_RS16695 3596518..3596865 + 348 WP_149566822.1 IS66 family insertion sequence element accessory protein TnpB -
EW093_RS16700 3596907..3598475 + 1569 WP_149566823.1 IS66 family transposase -
EW093_RS16705 3598543..3598836 + 294 WP_149567402.1 hypothetical protein -
EW093_RS16710 3598836..3599183 + 348 WP_149567401.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(3-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-70)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10289.03 Da        Isoelectric Point: 10.2525

>T118539 WP_149569486.1 NZ_CP035807:c3594811-3594551 [Thiospirochaeta perfilievii]
MYKLLYTKQSQKDAKKLASSNLKNKAKEILSQLEKDPFIDYPPYEKLIGDLTGSYSRRINIQHRIVYQVLEDKKIVKVLR
MWTHYQ

Download         Length: 261 bp

>T118539 NZ_CP035807:c3594811-3594551 [Thiospirochaeta perfilievii]
ATGTATAAATTATTGTATACTAAACAATCACAAAAAGATGCTAAAAAGTTAGCATCATCAAATCTAAAAAATAAAGCCAA
AGAAATATTATCGCAATTGGAAAAGGATCCTTTTATAGATTATCCACCTTATGAAAAATTAATTGGAGATTTAACAGGTT
CATATTCAAGGCGAATTAATATTCAACATAGAATAGTATATCAAGTTTTAGAAGATAAAAAAATAGTAAAAGTACTTCGA
ATGTGGACTCATTATCAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9043.22 Da        Isoelectric Point: 4.1677

>AT118539 WP_149569487.1 NZ_CP035807:c3595053-3594811 [Thiospirochaeta perfilievii]
MSNMNITTARKDLYKIVKSVNETHEPVFITGKNSSAILIGEEDWRSIQETLLLTSIPGMRESIIEGMNTDTDELSVDLDW

Download         Length: 243 bp

>AT118539 NZ_CP035807:c3595053-3594811 [Thiospirochaeta perfilievii]
ATGAGTAATATGAATATTACAACTGCAAGAAAAGATTTATATAAAATAGTTAAAAGTGTTAATGAAACTCATGAGCCTGT
TTTTATTACTGGGAAAAATTCTTCAGCAATTTTGATTGGAGAAGAAGATTGGCGTAGTATACAAGAAACATTGTTACTCA
CATCAATCCCTGGAATGAGAGAATCTATAATTGAAGGTATGAATACAGATACGGATGAATTATCTGTAGATTTGGATTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References