Detailed information of TA system TA118533

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 421476..421986
• Replicon: chromosome
• Accession: NZ_CP035807
• Organism: Thiospirochaeta perfilievii strain P

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: EW093_RS01875
• Protein ID: WP_149566760.1
• Coordinates: 421476..421739 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: EW093_RS01880
• Protein ID: WP_149566761.1
• Coordinates: 421732..421986 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EW093_RS01855	417237..418319	-	1083	WP_149566756.1	glycerol dehydrogenase	-
EW093_RS01860	418472..419425	-	954	WP_149566757.1	PocR ligand-binding domain-containing protein	-
EW093_RS01865	419942..420433	-	492	WP_149566758.1	hypothetical protein	-
EW093_RS01870	420433..421107	-	675	WP_149566759.1	hypothetical protein	-
EW093_RS01875	421476..421739	-	264	WP_149566760.1	Txe/YoeB family addiction module toxin	Toxin
EW093_RS01880	421732..421986	-	255	WP_149566761.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
EW093_RS17230	422242..422409	-	168	WP_187759788.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10512.11 Da
• Isoelectric Point: 9.8432

>T118533 WP_149566760.1 NZ_CP035807:c421739-421476 [Thiospirochaeta perfilievii]
MIERLSWTKEAWSDYLYWQGQDKKTLKRINKLIKDTMRTPYVGIGKPEELKKNLSGFWSRRIDHTNRLIYAVDEDLLSII
SCRYHYS

Nucleotide

• Length: 264 bp

>T118533 NZ_CP035807:c421739-421476 [Thiospirochaeta perfilievii]
ATGATTGAGAGATTATCCTGGACTAAAGAAGCTTGGTCTGATTATCTCTATTGGCAAGGACAGGATAAAAAGACTTTAAA
GCGTATAAATAAGCTGATCAAGGATACTATGAGAACTCCATATGTTGGGATTGGTAAACCTGAGGAACTTAAAAAAAATC
TCTCTGGATTTTGGTCTAGACGTATAGATCATACTAACAGGTTAATCTACGCTGTTGATGAAGATCTTCTATCAATAATT
TCGTGTCGTTATCATTATTCATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9528.54 Da
• Isoelectric Point: 4.5983

>AT118533 WP_149566761.1 NZ_CP035807:c421986-421732 [Thiospirochaeta perfilievii]
MRVINFSEARNNFKKVLDQVSDDADYTIISRRDSEDAVVMSLDQFNGLMETVHLLSSPANVKHLEKSIGQYRSGQTETHE
LADD

Nucleotide

• Length: 255 bp

>AT118533 NZ_CP035807:c421986-421732 [Thiospirochaeta perfilievii]
ATGAGAGTTATTAACTTTTCAGAAGCTAGAAACAACTTTAAAAAAGTTTTAGATCAGGTTTCAGATGATGCCGATTATAC
CATCATTTCAAGAAGAGACTCTGAGGACGCTGTTGTAATGTCTTTAGATCAATTTAATGGATTAATGGAAACTGTTCATT
TATTAAGTAGTCCTGCTAATGTTAAACATCTTGAGAAATCAATTGGACAGTATAGGTCTGGTCAGACAGAAACTCATGAG
CTAGCTGATGATTGA