Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2407389..2407906 Replicon chromosome
Accession NZ_CP035791
Organism Staphylococcus aureus strain 592

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag ERW13_RS12375 Protein ID WP_000113265.1
Coordinates 2407640..2407906 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag ERW13_RS12370 Protein ID WP_000584499.1
Coordinates 2407389..2407640 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ERW13_RS12340 2403087..2403806 + 720 WP_000479576.1 amino acid ABC transporter permease -
ERW13_RS12345 2403803..2404534 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
ERW13_RS12350 2404631..2405881 - 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
ERW13_RS12355 2406136..2406498 + 363 WP_000819843.1 DUF4467 domain-containing protein -
ERW13_RS12360 2406517..2407116 + 600 WP_000162810.1 DsbA family protein -
ERW13_RS12365 2407123..2407224 + 102 Protein_2287 hypothetical protein -
ERW13_RS12370 2407389..2407640 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ERW13_RS12375 2407640..2407906 + 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
ERW13_RS12380 2407941..2408012 + 72 Protein_2290 hypothetical protein -
ERW13_RS12385 2408201..2409748 + 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
ERW13_RS12390 2409934..2410401 + 468 WP_000153347.1 SRPBCC domain-containing protein -
ERW13_RS12395 2410485..2410667 + 183 WP_000230292.1 hypothetical protein -
ERW13_RS12400 2410884..2411708 + 825 WP_000572038.1 formate/nitrite transporter family protein -
ERW13_RS12405 2411942..2412478 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T118520 WP_000113265.1 NZ_CP035791:2407640-2407906 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T118520 NZ_CP035791:2407640-2407906 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT118520 WP_000584499.1 NZ_CP035791:2407389-2407640 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT118520 NZ_CP035791:2407389-2407640 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References