Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2382182..2382366 Replicon chromosome
Accession NZ_CP035791
Organism Staphylococcus aureus strain 592

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag ERW13_RS12215 Protein ID WP_000482652.1
Coordinates 2382182..2382289 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2382306..2382366 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ERW13_RS12190 2377544..2378017 + 474 WP_000456486.1 GyrI-like domain-containing protein -
ERW13_RS12195 2378140..2379351 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
ERW13_RS12200 2379533..2380192 - 660 WP_000831298.1 membrane protein -
ERW13_RS12205 2380252..2381394 - 1143 WP_001176863.1 glycerate kinase -
ERW13_RS12210 2381662..2382048 + 387 WP_000779360.1 flippase GtxA -
ERW13_RS12215 2382182..2382289 + 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2382306..2382366 - 61 - - Antitoxin
ERW13_RS12225 2382992..2384755 + 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
ERW13_RS12230 2384780..2386513 + 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
ERW13_RS12240 2386744..2386911 + 168 Protein_2265 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T118518 WP_000482652.1 NZ_CP035791:2382182-2382289 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T118518 NZ_CP035791:2382182-2382289 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT118518 NZ_CP035791:c2382366-2382306 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References