Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3818563..3819256 Replicon chromosome
Accession NZ_CP035770
Organism Escherichia coli O145 strain RM8988-C1

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag EW646_RS18960 Protein ID WP_000415584.1
Coordinates 3818960..3819256 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag EW646_RS18955 Protein ID WP_000650107.1
Coordinates 3818563..3818958 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW646_RS18945 3814427..3816685 - 2259 WP_001281878.1 DNA topoisomerase IV subunit A -
EW646_RS18950 3816823..3818430 - 1608 WP_001400746.1 ABC transporter substrate-binding protein -
EW646_RS18955 3818563..3818958 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
EW646_RS18960 3818960..3819256 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
EW646_RS18965 3819461..3819943 - 483 WP_000183497.1 GyrI-like domain-containing protein -
EW646_RS18970 3819996..3820388 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
EW646_RS18975 3820540..3821199 + 660 WP_001221502.1 two-component system response regulator QseB -
EW646_RS18980 3821196..3822545 + 1350 WP_000673396.1 two-component system sensor histidine kinase QseC -
EW646_RS18985 3822627..3822923 - 297 WP_000912118.1 DUF2645 family protein -
EW646_RS18990 3823281..3823862 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
EW646_RS18995 3823893..3824207 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T118471 WP_000415584.1 NZ_CP035770:c3819256-3818960 [Escherichia coli O145]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T118471 NZ_CP035770:c3819256-3818960 [Escherichia coli O145]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGACTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT118471 WP_000650107.1 NZ_CP035770:c3818958-3818563 [Escherichia coli O145]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT118471 NZ_CP035770:c3818958-3818563 [Escherichia coli O145]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACACAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References