Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-MqsA |
| Location | 560584..561217 | Replicon | chromosome |
| Accession | NZ_CP035689 | ||
| Organism | Vibrio metoecus strain 08-2459 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMA6 |
| Locus tag | EWA65_RS16155 | Protein ID | WP_000843587.1 |
| Coordinates | 560885..561217 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | EWA65_RS16150 | Protein ID | WP_000071008.1 |
| Coordinates | 560584..560898 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EWA65_RS16105 | 555744..555990 | - | 247 | Protein_564 | DUF3709 domain-containing protein | - |
| EWA65_RS16110 | 556280..556579 | - | 300 | WP_141237828.1 | hypothetical protein | - |
| EWA65_RS16115 | 556583..556981 | - | 399 | WP_055034289.1 | DUF2924 domain-containing protein | - |
| EWA65_RS16120 | 557238..557366 | - | 129 | WP_154139390.1 | DUF645 family protein | - |
| EWA65_RS18875 | 557641..558282 | - | 642 | WP_195708069.1 | hypothetical protein | - |
| EWA65_RS16130 | 558350..558763 | - | 414 | WP_154139261.1 | VOC family protein | - |
| EWA65_RS16135 | 558967..559416 | - | 450 | WP_154139262.1 | hypothetical protein | - |
| EWA65_RS16140 | 559538..559659 | - | 122 | Protein_571 | DUF3265 domain-containing protein | - |
| EWA65_RS16145 | 560007..560117 | - | 111 | WP_086017781.1 | DUF3265 domain-containing protein | - |
| EWA65_RS16150 | 560584..560898 | - | 315 | WP_000071008.1 | DNA-binding transcriptional regulator | Antitoxin |
| EWA65_RS16155 | 560885..561217 | - | 333 | WP_000843587.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| EWA65_RS16160 | 561407..561844 | - | 438 | WP_055028344.1 | NUDIX pyrophosphatase | - |
| EWA65_RS16165 | 562007..562222 | - | 216 | WP_154139263.1 | DUF645 family protein | - |
| EWA65_RS16175 | 562651..562911 | - | 261 | WP_162807037.1 | DUF3709 domain-containing protein | - |
| EWA65_RS16180 | 562881..563030 | - | 150 | Protein_578 | DUF3709 domain-containing protein | - |
| EWA65_RS16185 | 563030..563170 | - | 141 | WP_195708057.1 | DUF3265 domain-containing protein | - |
| EWA65_RS16190 | 563686..563874 | - | 189 | Protein_580 | DUF645 family protein | - |
| EWA65_RS16195 | 564179..564481 | - | 303 | WP_154139265.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| EWA65_RS16200 | 564469..564726 | - | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| EWA65_RS16205 | 564917..565276 | - | 360 | WP_055028343.1 | VOC family protein | - |
| EWA65_RS16215 | 565429..565815 | - | 387 | WP_055028342.1 | MmcQ/YjbR family DNA-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 453640..607302 | 153662 | |
| - | inside | Integrative and Conjugative Element | - | hlyA | 504927..845208 | 340281 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 13005.95 Da Isoelectric Point: 9.9244
>T118264 WP_000843587.1 NZ_CP035689:c561217-560885 [Vibrio metoecus]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
Download Length: 333 bp
>T118264 NZ_CP035689:c561217-560885 [Vibrio metoecus]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAGTATCTCAGTGATGAAGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAATCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGTAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCCGATTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAGTATCTCAGTGATGAAGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAATCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGTAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCCGATTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11696.20 Da Isoelectric Point: 6.7600
>AT118264 WP_000071008.1 NZ_CP035689:c560898-560584 [Vibrio metoecus]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
Download Length: 315 bp
>AT118264 NZ_CP035689:c560898-560584 [Vibrio metoecus]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAACAGCATTCAGAAGGTAAGCTTACGCT
GAAAACACATCATGTGAATGACGTGGGAGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTTAATA
TGTCCCGCGGAGTTTTCGCGCGGTTACTTCATACGTCTTCACGCACATTAGAAAACTGGGAACAAGGTCGTAGCGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAACAGCATTCAGAAGGTAAGCTTACGCT
GAAAACACATCATGTGAATGACGTGGGAGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTTAATA
TGTCCCGCGGAGTTTTCGCGCGGTTACTTCATACGTCTTCACGCACATTAGAAAACTGGGAACAAGGTCGTAGCGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|