Detailed information of TA system TA118224

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2554192..2554372
• Replicon: chromosome
• Accession: NZ_CP035671
• Organism: Staphylococcus aureus strain VB31683

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: EWG56_RS13240
• Protein ID: WP_001801861.1
• Coordinates: 2554277..2554372 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2554192..2554249 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EWG56_RS13205	2549218..2550399	+	1182	WP_000162901.1	hypothetical protein	-
EWG56_RS13210	2550714..2551013	-	300	WP_000095392.1	WXG100 family type VII secretion target	-
EWG56_RS13215	2551028..2552641	-	1614	WP_000926708.1	lipase	-
EWG56_RS13220	2552686..2553126	+	441	WP_000759947.1	DUF1433 domain-containing protein	-
EWG56_RS13225	2553332..2553709	+	378	WP_001036002.1	DUF1433 domain-containing protein	-
EWG56_RS13230	2553903..2554075	+	173	Protein_2450	transposase	-
EWG56_RS13235	2554053..2554154	-	102	WP_001791232.1	hypothetical protein	-
-	2554192..2554249	+	58	-	-	Antitoxin
EWG56_RS13240	2554277..2554372	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
EWG56_RS13245	2554517..2554621	+	105	WP_001670380.1	transposase	-
EWG56_RS13255	2555201..2555584	+	384	WP_000070809.1	hypothetical protein	-
EWG56_RS13260	2555595..2555771	+	177	WP_000375476.1	hypothetical protein	-
EWG56_RS13270	2556143..2556712	+	570	WP_000864144.1	ImmA/IrrE family metallo-endopeptidase	-
EWG56_RS13275	2556909..2557481	-	573	WP_000414208.1	hypothetical protein	-
EWG56_RS13280	2557582..2557923	-	342	WP_000627535.1	DUF3969 family protein	-
EWG56_RS13285	2557964..2558590	-	627	WP_000669029.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk	2535766..2581519	45753

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (6-99)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T118224 WP_001801861.1 NZ_CP035671:c2554372-2554277 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T118224 NZ_CP035671:c2554372-2554277 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT118224 NZ_CP035671:2554192-2554249 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin