Detailed information of TA system TA118220

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2383174..2383512
• Replicon: chromosome
• Accession: NZ_CP035671
• Organism: Staphylococcus aureus strain VB31683

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: EWG56_RS12120
• Protein ID: WP_072357969.1
• Coordinates: 2383174..2383350 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2383338..2383512 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EWG56_RS12100	2378408..2382192	+	3785	Protein_2276	hypothetical protein	-
EWG56_RS12105	2382182..2382334	+	153	WP_001153681.1	hypothetical protein	-
EWG56_RS12110	2382381..2382668	+	288	WP_001040261.1	hypothetical protein	-
EWG56_RS12115	2382726..2383022	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
EWG56_RS12120	2383174..2383350	+	177	WP_072357969.1	putative holin-like toxin	Toxin
-	2383338..2383512	-	175	-	-	Antitoxin
EWG56_RS12130	2383562..2383816	+	255	WP_000611512.1	phage holin	-
EWG56_RS12135	2383828..2384583	+	756	WP_000861038.1	CHAP domain-containing protein	-
EWG56_RS12140	2384774..2385265	+	492	WP_000920041.1	staphylokinase	-
EWG56_RS12160	2385916..2386250	+	335	Protein_2285	SH3 domain-containing protein	-
EWG56_RS12165	2386343..2386792	-	450	WP_000727643.1	chemotaxis-inhibiting protein CHIPS	-
EWG56_RS12170	2387474..2387824	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
EWG56_RS12175	2387877..2388137	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	2333834..2387824	53990

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T118220 WP_072357969.1 NZ_CP035671:2383174-2383350 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T118220 NZ_CP035671:2383174-2383350 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT118220 NZ_CP035671:c2383512-2383338 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin