Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2207735..2208014 Replicon chromosome
Accession NZ_CP035671
Organism Staphylococcus aureus strain VB31683

Toxin (Protein)


Gene name SprG3 Uniprot ID -
Locus tag EWG56_RS11120 Protein ID WP_075583739.1
Coordinates 2207735..2207839 (+) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2207835..2208014 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EWG56_RS11090 2204534..2205316 + 783 WP_000908181.1 ABC transporter ATP-binding protein -
EWG56_RS11095 2205384..2206240 + 857 Protein_2089 HAD family phosphatase -
EWG56_RS11105 2206900..2207058 - 159 WP_024928151.1 hypothetical protein -
EWG56_RS11115 2207476..2207637 + 162 Protein_2091 helix-turn-helix domain-containing protein -
EWG56_RS11120 2207735..2207839 + 105 WP_075583739.1 hypothetical protein Toxin
- 2207835..2208014 - 180 - - Antitoxin
EWG56_RS11125 2208354..2209445 - 1092 WP_000495680.1 hypothetical protein -
EWG56_RS11130 2209711..2210691 - 981 WP_000019744.1 CDF family zinc efflux transporter CzrB -
EWG56_RS11135 2210693..2211013 - 321 WP_000003755.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
EWG56_RS11140 2211165..2211830 + 666 WP_001024097.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3861.73 Da        Isoelectric Point: 7.0039

>T118215 WP_075583739.1 NZ_CP035671:2207735-2207839 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISNQGHKK

Download         Length: 105 bp

>T118215 NZ_CP035671:2207735-2207839 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTAATCAAGGCCATAAAAAATAA

Antitoxin


Download         Length: 180 bp

>AT118215 NZ_CP035671:c2208014-2207835 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGTAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References