Detailed information of TA system TA118213

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1947414..1947931
• Replicon: chromosome
• Accession: NZ_CP035671
• Organism: Staphylococcus aureus strain VB31683

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: EWG56_RS09715
• Protein ID: WP_000113261.1
• Coordinates: 1947665..1947931 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: EWG56_RS09710
• Protein ID: WP_000584499.1
• Coordinates: 1947414..1947665 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EWG56_RS09680	1943126..1943845	+	720	WP_000479573.1	amino acid ABC transporter permease	-
EWG56_RS09685	1943842..1944573	+	732	WP_000615455.1	amino acid ABC transporter ATP-binding protein	-
EWG56_RS09690	1944658..1945908	-	1251	WP_070149310.1	FemA/FemB family glycyltransferase FmhA	-
EWG56_RS09695	1946163..1946525	+	363	WP_000819843.1	DUF4467 domain-containing protein	-
EWG56_RS09700	1946544..1947143	+	600	WP_000162810.1	DsbA family protein	-
EWG56_RS09705	1947150..1947251	+	102	Protein_1828	hypothetical protein	-
EWG56_RS09710	1947414..1947665	+	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EWG56_RS09715	1947665..1947931	+	267	WP_000113261.1	Txe/YoeB family addiction module toxin	Toxin
EWG56_RS09720	1948225..1949775	+	1551	WP_000727760.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
EWG56_RS09725	1949961..1950428	+	468	WP_000153345.1	SRPBCC domain-containing protein	-
EWG56_RS09730	1950515..1950697	+	183	WP_000250735.1	hypothetical protein	-
EWG56_RS09735	1950900..1951724	+	825	WP_000594640.1	formate/nitrite transporter family protein	-
EWG56_RS09740	1951958..1952494	+	537	WP_000169319.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10452.02 Da
• Isoelectric Point: 10.0373

>T118213 WP_000113261.1 NZ_CP035671:1947665-1947931 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDKHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T118213 NZ_CP035671:1947665-1947931 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAAGCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT118213 WP_000584499.1 NZ_CP035671:1947414-1947665 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT118213 NZ_CP035671:1947414-1947665 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAGCACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Structures

Antitoxin

• AlphaFold DB: T1YB60