Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1889460..1889983 Replicon chromosome
Accession NZ_CP035671
Organism Staphylococcus aureus strain VB31683

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag EWG56_RS09410 Protein ID WP_000074048.1
Coordinates 1889717..1889983 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag EWG56_RS09405 Protein ID WP_000587616.1
Coordinates 1889460..1889717 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EWG56_RS09385 1885958..1886707 - 750 WP_000072439.1 hypothetical protein -
EWG56_RS09390 1886902..1888479 + 1578 WP_000143486.1 FMN-binding glutamate synthase family protein -
EWG56_RS09395 1888647..1889102 - 456 WP_000732082.1 DUF1307 domain-containing protein -
EWG56_RS09405 1889460..1889717 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EWG56_RS09410 1889717..1889983 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
EWG56_RS09415 1890338..1891414 + 1077 WP_001076687.1 M42 family metallopeptidase -
EWG56_RS09420 1891760..1892422 + 663 WP_000923509.1 ATP-binding cassette domain-containing protein -
EWG56_RS09425 1892415..1893191 + 777 WP_000072155.1 iron export ABC transporter permease subunit FetB -
EWG56_RS09430 1893585..1894772 + 1188 WP_000026196.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T118210 WP_000074048.1 NZ_CP035671:1889717-1889983 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T118210 NZ_CP035671:1889717-1889983 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT118210 WP_000587616.1 NZ_CP035671:1889460-1889717 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT118210 NZ_CP035671:1889460-1889717 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References