Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 280154..280689 Replicon plasmid unnamed1
Accession NZ_CP035661
Organism Enterococcus faecium strain UAMSEF_09

Toxin (Protein)


Gene name yoeB Uniprot ID R2PQC0
Locus tag EWM55_RS17330 Protein ID WP_002314366.1
Coordinates 280154..280426 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q3Y220
Locus tag EWM55_RS17335 Protein ID WP_002297422.1
Coordinates 280426..280689 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EWM55_RS17290 275294..275938 + 645 Protein_314 transposase -
EWM55_RS17295 276014..276693 + 680 WP_002331383.1 IS6-like element IS1216 family transposase -
EWM55_RS17300 276752..276940 - 189 Protein_316 hypothetical protein -
EWM55_RS17305 276941..277603 - 663 Protein_317 AAA family ATPase -
EWM55_RS17315 278993..279187 - 195 Protein_319 ParA family protein -
EWM55_RS17320 279472..279758 - 287 Protein_320 type II toxin-antitoxin system RelE/ParE family toxin -
EWM55_RS17325 279748..280077 - 330 WP_002292678.1 AbrB family transcriptional regulator -
EWM55_RS17330 280154..280426 - 273 WP_002314366.1 Txe/YoeB family addiction module toxin Toxin
EWM55_RS17335 280426..280689 - 264 WP_002297422.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EWM55_RS17340 280923..281832 + 910 Protein_324 IS982 family transposase -
EWM55_RS17345 281835..283010 - 1176 WP_002336205.1 MFS transporter -
EWM55_RS17350 283013..285262 - 2250 WP_106017163.1 alpha-galactosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid VanHAX / erm(B) - 1..295052 295052
- inside IScluster/Tn - - 267201..293680 26479


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10780.24 Da        Isoelectric Point: 9.9724

>T118193 WP_002314366.1 NZ_CP035661:c280426-280154 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ

Download         Length: 273 bp

>T118193 NZ_CP035661:c280426-280154 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9959.22 Da        Isoelectric Point: 4.5370

>AT118193 WP_002297422.1 NZ_CP035661:c280689-280426 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL

Download         Length: 264 bp

>AT118193 NZ_CP035661:c280689-280426 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829F704

Antitoxin

Source ID Structure
AlphaFold DB A0A829F006

References