Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
Location | 242064..242599 | Replicon | plasmid unnamed1 |
Accession | NZ_CP035655 | ||
Organism | Enterococcus faecium strain UAMSEF_08 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | R2PQC0 |
Locus tag | EWM54_RS16240 | Protein ID | WP_002314366.1 |
Coordinates | 242064..242336 (-) | Length | 91 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | Q3Y220 |
Locus tag | EWM54_RS16245 | Protein ID | WP_002297422.1 |
Coordinates | 242336..242599 (-) | Length | 88 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EWM54_RS16200 | 237202..237846 | + | 645 | Protein_269 | transposase | - |
EWM54_RS16205 | 237922..238602 | + | 681 | WP_002331383.1 | IS6-like element IS1216 family transposase | - |
EWM54_RS16210 | 238661..238849 | - | 189 | Protein_271 | hypothetical protein | - |
EWM54_RS16215 | 238850..239512 | - | 663 | Protein_272 | AAA family ATPase | - |
EWM54_RS16225 | 240902..241097 | - | 196 | Protein_274 | ParA family protein | - |
EWM54_RS16230 | 241382..241668 | - | 287 | Protein_275 | type II toxin-antitoxin system RelE/ParE family toxin | - |
EWM54_RS16235 | 241658..241987 | - | 330 | WP_002292678.1 | AbrB family transcriptional regulator | - |
EWM54_RS16240 | 242064..242336 | - | 273 | WP_002314366.1 | Txe/YoeB family addiction module toxin | Toxin |
EWM54_RS16245 | 242336..242599 | - | 264 | WP_002297422.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
EWM54_RS16250 | 242833..243741 | + | 909 | Protein_279 | IS982 family transposase | - |
EWM54_RS16255 | 243744..244919 | - | 1176 | WP_002336205.1 | MFS transporter | - |
EWM54_RS16260 | 244922..247171 | - | 2250 | WP_106017163.1 | alpha-galactosidase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..256961 | 256961 | |
- | inside | IScluster/Tn | - | - | 229109..255589 | 26480 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 91 a.a. Molecular weight: 10780.24 Da Isoelectric Point: 9.9724
>T118188 WP_002314366.1 NZ_CP035655:c242336-242064 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ
Download Length: 273 bp
>T118188 NZ_CP035655:c242336-242064 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA
Antitoxin
Download Length: 88 a.a. Molecular weight: 9959.22 Da Isoelectric Point: 4.5370
>AT118188 WP_002297422.1 NZ_CP035655:c242599-242336 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL
Download Length: 264 bp
>AT118188 NZ_CP035655:c242599-242336 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829F704 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829F006 |