Detailed information of TA system TA118153

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HTH_XRE
• Location: 67327..68038
• Replicon: plasmid pYU07-18_89
• Accession: NZ_CP035549
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain YU07-18

Toxin (Protein)

• Gene name: higB
• Uniprot ID: I2UJZ0
• Locus tag: D6D39_RS24875
• Protein ID: WP_000162415.1
• Coordinates: 67327..67629 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: D6D39_RS24880
• Protein ID: WP_000806445.1
• Coordinates: 67700..68038 (+)
• Length: 113 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D6D39_RS24845	62346..63026	-	681	WP_000812238.1	hypothetical protein	-
D6D39_RS24850	63010..63915	-	906	WP_001258018.1	recombination-associated protein RdgC	-
D6D39_RS24855	63975..64628	-	654	WP_000828868.1	hypothetical protein	-
D6D39_RS24860	64625..65605	-	981	WP_000046500.1	hypothetical protein	-
D6D39_RS24865	65609..66376	-	768	WP_000203293.1	hypothetical protein	-
D6D39_RS24870	66373..67164	-	792	WP_001557712.1	hypothetical protein	-
D6D39_RS24875	67327..67629	+	303	WP_000162415.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D6D39_RS24880	67700..68038	+	339	WP_000806445.1	HigA family addiction module antidote protein	Antitoxin
D6D39_RS24885	68095..68454	+	360	WP_022630906.1	transcriptional regulator	-
D6D39_RS25225	68516..69253	+	738	WP_022630905.1	hypothetical protein	-
D6D39_RS24895	69287..70483	-	1197	WP_022630904.1	hypothetical protein	-
D6D39_RS24900	70476..70805	-	330	WP_000542383.1	hypothetical protein	-
D6D39_RS24905	71134..71787	-	654	WP_001557715.1	hypothetical protein	-
D6D39_RS24910	72055..72966	+	912	WP_024144056.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..88898	88898

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-44)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 12963.60 Da
• Isoelectric Point: 12.8000

>T118153 WP_000162415.1 NZ_CP035549:67327-67629 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 303 bp

>T118153 NZ_CP035549:67327-67629 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 113 a.a.
• Molecular weight: 14501.69 Da
• Isoelectric Point: 12.8492

>AT118153 WP_000806445.1 NZ_CP035549:67700-68038 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 339 bp

>AT118153 NZ_CP035549:67700-68038 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: A0A631VBQ3