Detailed information of TA system TA118143

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-ohsC/Ldr(toxin)
• Location: 4456565..4456786
• Replicon: chromosome
• Accession: NZ_CP035545
• Organism: Escherichia coli strain FSIS11705876

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: EB814_RS22460
• Protein ID: WP_001295224.1
• Coordinates: 4456565..4456672 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	4456721..4456786 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EB814_RS22435	4451818..4452570	-	753	Protein_4377	cellulose biosynthesis protein BcsQ	-
EB814_RS22440	4452582..4452770	-	189	WP_001063316.1	YhjR family protein	-
EB814_RS22445	4453043..4454614	+	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
EB814_RS22450	4454611..4454802	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
EB814_RS22455	4454799..4456478	+	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
EB814_RS22460	4456565..4456672	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4456721..4456786	+	66	NuclAT_16	-	Antitoxin
-	4456721..4456786	+	66	NuclAT_16	-	Antitoxin
-	4456721..4456786	+	66	NuclAT_16	-	Antitoxin
-	4456721..4456786	+	66	NuclAT_16	-	Antitoxin
-	4456721..4456786	+	66	NuclAT_21	-	Antitoxin
-	4456721..4456786	+	66	NuclAT_21	-	Antitoxin
-	4456721..4456786	+	66	NuclAT_21	-	Antitoxin
-	4456721..4456786	+	66	NuclAT_21	-	Antitoxin
EB814_RS22465	4457148..4458419	+	1272	WP_001301684.1	amino acid permease	-
EB814_RS22470	4458449..4459453	-	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
EB814_RS22475	4459450..4460433	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
EB814_RS22480	4460444..4461346	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T118143 WP_001295224.1 NZ_CP035545:c4456672-4456565 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T118143 NZ_CP035545:c4456672-4456565 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT118143 NZ_CP035545:4456721-4456786 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin