Detailed information of TA system TA118118

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1179579..1179804
• Replicon: chromosome
• Accession: NZ_CP035545
• Organism: Escherichia coli strain FSIS11705876

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: EB814_RS05435
• Protein ID: WP_000813263.1
• Coordinates: 1179649..1179804 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1179579..1179637 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EB814_RS05400	1174640..1175386	+	747	WP_000788745.1	ATP-binding protein	-
EB814_RS05405	1175408..1176094	+	687	WP_153983941.1	DUF1627 domain-containing protein	-
EB814_RS05410	1176146..1177358	+	1213	Protein_1058	IS3 family transposase	-
EB814_RS05415	1177401..1177490	+	90	Protein_1059	DUF1627 domain-containing protein	-
EB814_RS05420	1177506..1177919	+	414	WP_001151233.1	DUF977 family protein	-
EB814_RS05425	1178271..1179044	-	774	WP_000160654.1	alpha/beta hydrolase	-
-	1179579..1179637	-	59	-	-	Antitoxin
EB814_RS05435	1179649..1179804	+	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
EB814_RS05440	1179972..1180250	+	279	WP_001341388.1	hypothetical protein	-
EB814_RS05445	1180252..1181301	+	1050	WP_001265172.1	DUF968 domain-containing protein	-
EB814_RS05450	1181314..1181685	+	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
EB814_RS05455	1181675..1182046	+	372	WP_000090264.1	antitermination protein	-
EB814_RS05460	1182198..1183016	+	819	WP_000265265.1	CPBP family intramembrane metalloprotease	-
EB814_RS05465	1183303..1183499	+	197	Protein_1068	TrmB family transcriptional regulator	-
EB814_RS05470	1183637..1184350	+	714	WP_000261909.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T118118 WP_000813263.1 NZ_CP035545:1179649-1179804 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T118118 NZ_CP035545:1179649-1179804 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT118118 NZ_CP035545:c1179637-1179579 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin