Detailed information of TA system TA118017

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 828321..828854
• Replicon: chromosome
• Accession: NZ_CP035504
• Organism: Kocuria indica strain CE7

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: KocCE7_RS03730
• Protein ID: WP_131332532.1
• Coordinates: 828600..828854 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: KocCE7_RS03725
• Protein ID: WP_131332531.1
• Coordinates: 828321..828599 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KocCE7_RS03710	824864..825613	+	750	WP_131332528.1	M48 family metallopeptidase	-
KocCE7_RS03715	825923..826558	-	636	WP_131332529.1	hypothetical protein	-
KocCE7_RS03720	826904..828172	+	1269	WP_131332530.1	ATP-binding protein	-
KocCE7_RS03725	828321..828599	+	279	WP_131332531.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
KocCE7_RS03730	828600..828854	+	255	WP_131332532.1	Txe/YoeB family addiction module toxin	Toxin
KocCE7_RS03735	828977..829513	+	537	WP_131332533.1	GNAT family N-acetyltransferase	-
KocCE7_RS03740	829678..831108	+	1431	WP_131332534.1	anion permease	-
KocCE7_RS03745	831197..831946	-	750	WP_131332535.1	succinate dehydrogenase/fumarate reductase iron-sulfur subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-67)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10141.57 Da
• Isoelectric Point: 7.1630

>T118017 WP_131332532.1 NZ_CP035504:828600-828854 [Kocuria indica]
MRLVWDEAAWEDYTYWQTADRRILKRINLLIDACLREPFEGIGKPEQLKYGARGSWSRRINEEHRVVYLVTGEDLVILQA
RYHY

Nucleotide

• Length: 255 bp

>T118017 NZ_CP035504:828600-828854 [Kocuria indica]
ATGCGGCTGGTCTGGGACGAGGCCGCCTGGGAGGACTACACGTACTGGCAGACCGCCGACCGGAGAATCCTCAAACGGAT
CAACCTGCTCATCGATGCCTGCCTGCGCGAGCCGTTCGAGGGCATCGGCAAGCCGGAGCAGTTGAAGTACGGGGCGCGGG
GCTCGTGGTCGCGGCGCATCAACGAGGAGCACCGGGTCGTCTACCTCGTGACTGGTGAGGATCTCGTGATCTTGCAGGCT
CGCTACCACTACTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10442.60 Da
• Isoelectric Point: 4.8723

>AT118017 WP_131332531.1 NZ_CP035504:828321-828599 [Kocuria indica]
MSISASEARKTLFPLIERVNEDQEAVEIVSRKGNAVLMPADEYAAWQETAYLFRSPSNARRLLDAYDRARVGKTQVHELD
RSDESVSQSRDV

Nucleotide

• Length: 279 bp

>AT118017 NZ_CP035504:828321-828599 [Kocuria indica]
ATGTCCATCAGCGCAAGCGAGGCCCGCAAGACTCTCTTCCCGCTCATCGAGCGCGTGAACGAGGACCAGGAAGCCGTCGA
GATCGTCTCTCGGAAGGGCAACGCGGTGCTCATGCCTGCCGACGAGTACGCGGCGTGGCAGGAGACCGCCTACCTGTTCC
GGTCGCCGTCGAACGCCCGCAGGCTGCTCGACGCCTACGATCGTGCCCGTGTCGGGAAGACCCAGGTCCACGAGCTCGAC
CGTTCCGACGAGTCGGTCAGCCAGTCTCGGGACGTCTGA