Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4398402..4398660 Replicon chromosome
Accession NZ_CP035498
Organism Escherichia coli strain 04-00955

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag EQO00_RS21815 Protein ID WP_000809168.1
Coordinates 4398508..4398660 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4398402..4398459 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQO00_RS21800 4394231..4395490 - 1260 WP_000494929.1 hypothetical protein -
EQO00_RS21805 4395619..4397112 - 1494 WP_001350365.1 sulfatase-like hydrolase/transferase -
EQO00_RS21810 4397132..4397893 - 762 WP_001274832.1 hypothetical protein -
- 4398402..4398459 - 58 - - Antitoxin
EQO00_RS21815 4398508..4398660 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
EQO00_RS21820 4398765..4399895 - 1131 WP_001118464.1 molecular chaperone DnaJ -
EQO00_RS21825 4399984..4401900 - 1917 WP_000516135.1 molecular chaperone DnaK -
EQO00_RS21830 4402272..4402676 + 405 WP_000843692.1 DUF2541 family protein -
EQO00_RS21835 4402702..4403415 + 714 WP_001102393.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T118005 WP_000809168.1 NZ_CP035498:4398508-4398660 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T118005 NZ_CP035498:4398508-4398660 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT118005 NZ_CP035498:c4398459-4398402 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References