Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 6741063..6741750 Replicon chromosome
Accession NZ_CP035490
Organism Hahella sp. KA22

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EUZ85_RS29955 Protein ID WP_127973746.1
Coordinates 6741063..6741422 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EUZ85_RS29960 Protein ID WP_127973747.1
Coordinates 6741439..6741750 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EUZ85_RS29935 6738693..6738890 - 198 WP_127973743.1 DNA-binding protein -
EUZ85_RS29940 6739150..6739470 + 321 WP_127973744.1 XRE family transcriptional regulator -
EUZ85_RS29945 6739510..6740562 + 1053 WP_127973745.1 tyrosine-type recombinase/integrase -
EUZ85_RS29955 6741063..6741422 + 360 WP_127973746.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EUZ85_RS29960 6741439..6741750 + 312 WP_127973747.1 XRE family transcriptional regulator Antitoxin
EUZ85_RS29965 6741776..6743563 + 1788 WP_164887395.1 DEAD/DEAH box helicase family protein -
EUZ85_RS29970 6744008..6744253 - 246 WP_127973749.1 hypothetical protein -
EUZ85_RS29975 6744243..6744722 - 480 WP_127973750.1 hypothetical protein -
EUZ85_RS29980 6744742..6746226 - 1485 WP_127974618.1 MobA/MobL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 6700285..6744722 44437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-84)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13568.68 Da        Isoelectric Point: 8.0084

>T117972 WP_127973746.1 NZ_CP035490:6741063-6741422 [Hahella sp. KA22]
MTWEILVTDEYEGWFLNLTDAEQIDVQAMVDVLEIKGPNLGRPQADTIKGTKKVKNLKELVIQHAGKPYRVFYAFDPKRR
AVLLCGGRKDGSKDKQFYKQMVPLAEAEFADHLKSEGLK

Download         Length: 360 bp

>T117972 NZ_CP035490:6741063-6741422 [Hahella sp. KA22]
ATGACGTGGGAAATATTAGTCACAGATGAATATGAGGGCTGGTTTCTAAATCTAACTGACGCTGAACAAATTGACGTTCA
AGCAATGGTTGACGTTCTGGAAATCAAAGGCCCTAACCTTGGCCGCCCTCAGGCAGATACGATAAAAGGCACAAAGAAGG
TTAAAAACCTTAAGGAGCTGGTCATTCAGCACGCAGGAAAACCATATAGAGTTTTCTATGCCTTTGACCCCAAACGACGC
GCTGTTCTTCTATGCGGTGGTCGAAAAGATGGATCGAAAGATAAACAGTTTTACAAACAGATGGTTCCGCTAGCTGAAGC
AGAGTTTGCGGATCACTTAAAAAGCGAAGGCCTCAAGTAG

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11129.92 Da        Isoelectric Point: 10.4004

>AT117972 WP_127973747.1 NZ_CP035490:6741439-6741750 [Hahella sp. KA22]
MAKPLSELRKQMSPEVQAAARAKAVGIVAEMSLAETRKLRGRSQAVVARALGIAQPNVSQIEKRPDTMISTLASYVEALG
GKLEIHAKFPDGQDVEITQFKQA

Download         Length: 312 bp

>AT117972 NZ_CP035490:6741439-6741750 [Hahella sp. KA22]
ATGGCAAAGCCTTTAAGCGAACTGCGCAAGCAAATGAGCCCTGAAGTACAAGCAGCCGCACGAGCAAAAGCAGTTGGCAT
AGTTGCAGAAATGTCACTGGCAGAAACTCGTAAGCTGCGTGGTCGCAGTCAAGCAGTGGTGGCTCGCGCCTTGGGTATAG
CCCAACCTAATGTTTCTCAAATTGAAAAACGCCCTGACACAATGATCAGCACACTGGCGTCTTATGTTGAAGCCTTAGGT
GGAAAACTCGAAATCCATGCAAAATTTCCAGATGGGCAAGACGTGGAGATCACACAATTCAAACAAGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References