Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 4669763..4670295 Replicon chromosome
Accession NZ_CP035467
Organism Methylotuvimicrobium buryatense strain 5GB1C

Toxin (Protein)


Gene name yoeB Uniprot ID A0A4P9UUK0
Locus tag EQU24_RS20720 Protein ID WP_017841731.1
Coordinates 4669763..4670032 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A4P9UVB9
Locus tag EQU24_RS20725 Protein ID WP_017841730.1
Coordinates 4670035..4670295 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQU24_RS20695 4665933..4666877 + 945 WP_017841736.1 hypothetical protein -
EQU24_RS20700 4666899..4667144 + 246 WP_017841735.1 hypothetical protein -
EQU24_RS20705 4667353..4667709 - 357 WP_138767251.1 hypothetical protein -
EQU24_RS20710 4668360..4669367 + 1008 WP_026130284.1 fructose-bisphosphate aldolase class II -
EQU24_RS20720 4669763..4670032 - 270 WP_017841731.1 Txe/YoeB family addiction module toxin Toxin
EQU24_RS20725 4670035..4670295 - 261 WP_017841730.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EQU24_RS20730 4670509..4670757 + 249 WP_017841729.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
EQU24_RS20735 4670747..4671046 + 300 WP_017841728.1 type II toxin-antitoxin system RelE/ParE family toxin -
EQU24_RS20740 4671123..4671458 - 336 WP_083877766.1 toll/interleukin-1 receptor domain-containing protein -
EQU24_RS20745 4671694..4672086 - 393 WP_051056250.1 DUF393 domain-containing protein -
EQU24_RS20750 4672558..4674354 + 1797 WP_017841725.1 assimilatory sulfite reductase (NADPH) flavoprotein subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10596.05 Da        Isoelectric Point: 8.0424

>T117846 WP_017841731.1 NZ_CP035467:c4670032-4669763 [Methylotuvimicrobium buryatense]
MRVILFVPDAWEDYLYWQHQDNKTLKRLNLLITASARDPFTGIGKPEPLRGDLSGYWSRRIDDTNRLVYRATDTELVIIA
CRFHYESRH

Download         Length: 270 bp

>T117846 NZ_CP035467:c4670032-4669763 [Methylotuvimicrobium buryatense]
ATGCGTGTCATTCTATTTGTTCCCGATGCATGGGAGGATTATCTGTACTGGCAACATCAGGATAACAAAACGCTCAAGCG
GTTAAACCTCTTGATTACAGCCTCCGCGCGCGATCCGTTTACCGGAATCGGAAAGCCCGAACCGCTACGTGGCGATTTAT
CCGGTTACTGGTCACGACGCATAGATGATACAAACCGCCTGGTATATCGGGCAACCGATACAGAGTTAGTCATTATCGCT
TGCCGTTTTCATTACGAGAGCCGTCATTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9300.38 Da        Isoelectric Point: 4.9799

>AT117846 WP_017841730.1 NZ_CP035467:c4670295-4670035 [Methylotuvimicrobium buryatense]
MKVVTYTHARNALKSILDEVVQDADVTIISRRDAEGDAVVMSLDSYNSIMETLHLTSNPANAAALARAIAQDKAGQAQEH
QLHPSD

Download         Length: 261 bp

>AT117846 NZ_CP035467:c4670295-4670035 [Methylotuvimicrobium buryatense]
ATGAAAGTCGTTACCTACACCCATGCACGCAATGCTCTCAAGTCTATATTGGATGAGGTAGTACAAGATGCTGACGTTAC
CATTATCAGTCGTCGTGATGCAGAGGGTGATGCAGTGGTGATGTCGCTGGATAGCTACAACAGCATCATGGAGACATTGC
ACCTGACTAGTAATCCAGCGAACGCGGCGGCATTAGCCAGAGCCATCGCACAAGACAAAGCGGGACAGGCGCAAGAACAT
CAATTACACCCTAGTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P9UUK0

Antitoxin

Source ID Structure
AlphaFold DB A0A4P9UVB9

References