Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4115157..4115846 Replicon chromosome
Accession NZ_CP035466
Organism Klebsiella aerogenes strain LU2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ES159_RS20085 Protein ID WP_042894575.1
Coordinates 4115157..4115453 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ES159_RS20090 Protein ID WP_032711784.1
Coordinates 4115511..4115846 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ES159_RS20075 4113196..4114341 + 1146 Protein_3810 porin OmpC -
ES159_RS20080 4114486..4114920 + 435 WP_015366316.1 universal stress protein UspF -
ES159_RS20085 4115157..4115453 + 297 WP_042894575.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ES159_RS20090 4115511..4115846 + 336 WP_032711784.1 HigA family addiction module antidote protein Antitoxin
ES159_RS20095 4115883..4116149 + 267 Protein_3814 tyrosine-type recombinase/integrase -
ES159_RS20100 4116197..4117132 + 936 WP_032711785.1 tRNA 2-thiocytidine(32) synthetase TtcA -
ES159_RS20105 4117180..4118553 - 1374 WP_047042836.1 ATP-dependent RNA helicase DbpA -
ES159_RS20110 4119038..4120021 - 984 WP_015366313.1 zinc transporter ZntB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-96)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-84)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11554.16 Da        Isoelectric Point: 7.4629

>T117821 WP_042894575.1 NZ_CP035466:4115157-4115453 [Klebsiella aerogenes]
MQNHIGSFRDVWLEEFFLHSAPHKKIPPDIHTTLARKLDIINAAVTYLDLRSPPGNRYEELNGKLEGYSSIRINQQYRLI
FKWVDGKAEDLYLDPHKY

Download         Length: 297 bp

>T117821 NZ_CP035466:4115157-4115453 [Klebsiella aerogenes]
ATGCAGAATCACATAGGTAGCTTTCGTGATGTATGGTTGGAAGAGTTTTTTTTGCACTCGGCACCACATAAAAAAATTCC
TCCAGACATACATACCACGCTAGCTCGCAAACTCGATATCATCAATGCCGCCGTTACCTATCTGGATTTACGCTCGCCAC
CTGGTAATAGATATGAAGAGCTAAACGGCAAATTGGAAGGTTATTCGTCAATTAGAATTAACCAGCAGTACCGCTTAATA
TTTAAGTGGGTGGATGGAAAAGCGGAAGACCTTTACCTGGATCCGCACAAGTACTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12694.53 Da        Isoelectric Point: 7.2045

>AT117821 WP_032711784.1 NZ_CP035466:4115511-4115846 [Klebsiella aerogenes]
MKQATRKPTTVGDILQFEYLEPLDLKINELAEMIHVHRNSVSALVNNNRKLTTDMAFRLSKAFNTTVDFWLNLQAAVDLW
EVENDTRAQEEFSRIVPASKFIASKADKKVA

Download         Length: 336 bp

>AT117821 NZ_CP035466:4115511-4115846 [Klebsiella aerogenes]
ATGAAACAGGCAACCAGAAAACCAACTACCGTAGGTGACATCCTGCAGTTTGAATACCTGGAGCCGCTAGATTTAAAAAT
CAACGAACTTGCGGAAATGATACATGTGCATCGTAATAGTGTAAGTGCATTAGTTAACAACAACCGCAAACTAACTACTG
ACATGGCATTTCGCCTGTCTAAAGCCTTCAATACCACCGTTGATTTCTGGCTTAACCTTCAGGCTGCTGTAGATTTGTGG
GAGGTGGAGAATGACACCCGCGCGCAGGAAGAGTTTAGCCGCATTGTTCCCGCCTCGAAATTTATCGCCAGCAAAGCTGA
TAAGAAAGTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References