Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 881841..882364 Replicon chromosome
Accession NZ_CP035464
Organism Bifidobacterium pullorum subsp. gallinarum strain CACC 514

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag ESN35_RS03500 Protein ID WP_129238279.1
Coordinates 881841..882095 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag ESN35_RS03505 Protein ID WP_129237091.1
Coordinates 882098..882364 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ESN35_RS03485 878299..879426 + 1128 WP_129237088.1 LacI family transcriptional regulator -
ESN35_RS03490 879531..880052 - 522 WP_129237089.1 NUDIX domain-containing protein -
ESN35_RS03495 880138..881724 - 1587 WP_129237090.1 aminopeptidase P family protein -
ESN35_RS03500 881841..882095 - 255 WP_129238279.1 Txe/YoeB family addiction module toxin Toxin
ESN35_RS03505 882098..882364 - 267 WP_129237091.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ESN35_RS10485 882444..882656 + 213 WP_164999813.1 antitoxin VbhA family protein -
ESN35_RS03510 882783..883313 - 531 Protein_687 restriction endonuclease subunit S -
ESN35_RS03515 883344..883892 + 549 WP_129238280.1 restriction endonuclease subunit S -
ESN35_RS03520 883941..884864 + 924 WP_129238281.1 site-specific integrase -
ESN35_RS03525 885067..886725 + 1659 WP_129237092.1 bifunctional folylpolyglutamate synthase/dihydrofolate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(4-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10069.40 Da        Isoelectric Point: 7.8156

>T117814 WP_129238279.1 NZ_CP035464:c882095-881841 [Bifidobacterium pullorum subsp. gallinarum]
MLSWTEDAWNDYLYRQSQDRKTLKRINALIRDMKRSPFEGIGKPEPLKWDYQGAWSRRIDSANRIVYTVIGDDLCILSCR
DHYE

Download         Length: 255 bp

>T117814 NZ_CP035464:c882095-881841 [Bifidobacterium pullorum subsp. gallinarum]
ATGCTGAGCTGGACCGAGGATGCATGGAACGACTATCTTTACCGGCAAAGCCAGGACCGCAAGACGCTTAAACGTATCAA
CGCGCTTATCCGCGACATGAAGCGCAGTCCGTTCGAGGGCATCGGCAAGCCGGAGCCCCTGAAATGGGATTATCAGGGGG
CATGGTCGCGACGCATCGATTCCGCAAACCGGATTGTATACACGGTCATCGGCGACGACCTGTGCATCCTCTCCTGCCGA
GATCATTACGAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9938.15 Da        Isoelectric Point: 5.0477

>AT117814 WP_129237091.1 NZ_CP035464:c882364-882098 [Bifidobacterium pullorum subsp. gallinarum]
MVTAVTYSTFRNNLKSYLRKVNEDADTLLVTNTDPADDVVVIGKDDYESLMETMRIYNNPYLRDKIARGLAQARSGRLIH
NDPTTAEA

Download         Length: 267 bp

>AT117814 NZ_CP035464:c882364-882098 [Bifidobacterium pullorum subsp. gallinarum]
ATGGTCACAGCAGTCACCTACAGCACGTTCCGCAACAACCTCAAATCATATCTGCGCAAGGTCAACGAGGACGCGGATAC
GCTCCTCGTCACCAACACCGATCCCGCCGACGACGTGGTCGTCATAGGCAAGGACGATTACGAATCCCTCATGGAAACGA
TGCGCATCTACAACAACCCGTATCTCCGTGACAAAATCGCCCGCGGCCTGGCTCAGGCCCGCTCCGGACGCCTCATCCAC
AACGACCCGACCACGGCGGAAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References