Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 40527..40978 Replicon plasmid pFPPDNB1-1
Accession NZ_CP035459
Organism Photobacterium damselae subsp. damselae strain KC-Na-NB1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ETN89_RS19830 Protein ID WP_086368793.1
Coordinates 40799..40978 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ETN89_RS19825 Protein ID WP_086368794.1
Coordinates 40527..40802 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ETN89_RS19795 36159..36425 - 267 WP_129382760.1 hypothetical protein -
ETN89_RS19800 36864..37871 - 1008 WP_129382761.1 hypothetical protein -
ETN89_RS19805 38016..38414 - 399 WP_129382762.1 hypothetical protein -
ETN89_RS19810 38411..38932 - 522 WP_129382763.1 ParA family protein -
ETN89_RS19815 39496..39714 - 219 WP_086368796.1 hypothetical protein -
ETN89_RS19820 39714..40202 - 489 WP_086368795.1 hypothetical protein -
ETN89_RS19825 40527..40802 - 276 WP_086368794.1 helix-turn-helix domain-containing protein Antitoxin
ETN89_RS19830 40799..40978 - 180 WP_086368793.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ETN89_RS19835 41140..41817 - 678 WP_086368792.1 CPBP family intramembrane metalloprotease -
ETN89_RS19840 42055..42944 + 890 Protein_49 IS630 family transposase -
ETN89_RS19845 43278..43673 - 396 WP_086368791.1 hypothetical protein -
ETN89_RS21345 44903..45073 + 171 WP_165001294.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..75779 75779
- flank IS/Tn - - 42043..42636 593


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(2-55)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6825.12 Da        Isoelectric Point: 10.5907

>T117813 WP_086368793.1 NZ_CP035459:c40978-40799 [Photobacterium damselae subsp. damselae]
MGDGLFEIRAKAQEGIGRGLFCYLKGQHVYVLRAFVKKANKTQKKEIELARERMKEVKL

Download         Length: 180 bp

>T117813 NZ_CP035459:c40978-40799 [Photobacterium damselae subsp. damselae]
ATGGGAGATGGGCTTTTTGAAATAAGAGCTAAAGCTCAAGAAGGTATAGGTAGAGGTTTGTTTTGCTATTTAAAAGGACA
GCACGTTTATGTATTAAGAGCTTTTGTGAAAAAGGCGAATAAGACCCAAAAAAAAGAAATAGAACTTGCTAGAGAGCGAA
TGAAAGAGGTGAAGTTATGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10072.56 Da        Isoelectric Point: 8.9869

>AT117813 WP_086368794.1 NZ_CP035459:c40802-40527 [Photobacterium damselae subsp. damselae]
MNLSALKRKALQNPEVKEAYDDLSIEFELINSLISMREKSGLTQDEVAEKMGTKAPNISRLESGRSNPSLKTLVSYAQAC
GFKLNIGFKHA

Download         Length: 276 bp

>AT117813 NZ_CP035459:c40802-40527 [Photobacterium damselae subsp. damselae]
ATGAATTTATCTGCATTAAAAAGAAAAGCATTACAGAATCCTGAAGTAAAAGAAGCTTATGACGATCTAAGTATTGAATT
TGAATTGATAAATTCTCTAATTTCAATGAGAGAAAAATCAGGCTTAACTCAAGATGAAGTTGCTGAAAAAATGGGAACAA
AAGCCCCGAATATTTCGCGTTTAGAATCTGGACGATCAAATCCTAGTCTTAAAACTTTAGTGAGTTATGCTCAAGCATGT
GGATTTAAGCTAAATATTGGTTTTAAACATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References