Detailed information of TA system TA117774

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2564410..2564735
• Replicon: chromosome
• Accession: NZ_CP035413
• Organism: Bacillus subtilis strain SRCM103629

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: P54373
• Locus tag: ETL58_RS13370
• Protein ID: WP_004398662.1
• Coordinates: 2564410..2564589 (+)
• Length: 60 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2564513..2564735 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETL58_RS13360	2563636..2563773	-	138	WP_021480099.1	hypothetical protein	-
ETL58_RS13365	2563815..2564264	-	450	WP_032722171.1	phage portal protein	-
ETL58_RS13370	2564410..2564589	+	180	WP_004398662.1	type I toxin-antitoxin system toxin TxpA	Toxin
-	2564513..2564735	-	223	NuclAT_0	-	Antitoxin
-	2564513..2564735	-	223	NuclAT_0	-	Antitoxin
-	2564513..2564735	-	223	NuclAT_0	-	Antitoxin
-	2564513..2564735	-	223	NuclAT_0	-	Antitoxin
ETL58_RS13375	2564969..2565058	+	90	WP_075058862.1	type I toxin-antitoxin system toxin BsrH	-
ETL58_RS13380	2565312..2565755	-	444	WP_003229930.1	phage tail tube protein	-
ETL58_RS13385	2565758..2567158	-	1401	WP_129010212.1	phage tail sheath family protein	-
ETL58_RS13390	2567159..2567350	-	192	WP_033880532.1	hypothetical protein	-
ETL58_RS13395	2567347..2567784	-	438	WP_017697472.1	hypothetical protein	-
ETL58_RS13400	2567797..2568300	-	504	WP_017697473.1	HK97 gp10 family phage protein	-
ETL58_RS13405	2568297..2568659	-	363	WP_129010213.1	YqbH/XkdH family protein	-
ETL58_RS13410	2568656..2569051	-	396	WP_015714318.1	DUF3199 family protein	-
ETL58_RS13415	2569056..2569367	-	312	WP_015714319.1	YqbF domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2522197..2587025	64828

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6739.19 Da
• Isoelectric Point: 8.0370

>T117774 WP_004398662.1 NZ_CP035413:2564410-2564589 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Nucleotide

• Length: 180 bp

>T117774 NZ_CP035413:2564410-2564589 [Bacillus subtilis]
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG

Antitoxin

Nucleotide

• Length: 223 bp

>AT117774 NZ_CP035413:c2564735-2564513 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Structures

Toxin

• AlphaFold DB: A0A164X333

Antitoxin