Detailed information of TA system TA117745

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2446208..2446533
• Replicon: chromosome
• Accession: NZ_CP035397
• Organism: Bacillus subtilis strain SRCM103773

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: P54373
• Locus tag: ETA10_RS13200
• Protein ID: WP_004398662.1
• Coordinates: 2446208..2446387 (+)
• Length: 60 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2446311..2446533 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETA10_RS13190	2445434..2445571	-	138	WP_021480099.1	hypothetical protein	-
ETA10_RS13195	2445613..2446062	-	450	WP_032722171.1	phage portal protein	-
ETA10_RS13200	2446208..2446387	+	180	WP_004398662.1	type I toxin-antitoxin system toxin TxpA	Toxin
-	2446311..2446533	-	223	NuclAT_0	-	Antitoxin
-	2446311..2446533	-	223	NuclAT_0	-	Antitoxin
-	2446311..2446533	-	223	NuclAT_0	-	Antitoxin
-	2446311..2446533	-	223	NuclAT_0	-	Antitoxin
ETA10_RS13205	2446767..2446856	+	90	WP_075058862.1	type I toxin-antitoxin system toxin BsrH	-
ETA10_RS13210	2447110..2447553	-	444	WP_003229930.1	phage tail tube protein	-
ETA10_RS13215	2447556..2448956	-	1401	WP_003229929.1	phage tail sheath family protein	-
ETA10_RS13220	2448957..2449148	-	192	WP_010886574.1	hypothetical protein	-
ETA10_RS13225	2449145..2449582	-	438	WP_003229927.1	hypothetical protein	-
ETA10_RS13230	2449595..2450098	-	504	WP_003246050.1	HK97 gp10 family phage protein	-
ETA10_RS13235	2450095..2450457	-	363	WP_003229925.1	YqbH/XkdH family protein	-
ETA10_RS13240	2450454..2450849	-	396	WP_004398566.1	DUF3199 family protein	-
ETA10_RS13245	2450853..2451164	-	312	WP_003229923.1	YqbF domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2415631..2490227	74596

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6739.19 Da
• Isoelectric Point: 8.0370

>T117745 WP_004398662.1 NZ_CP035397:2446208-2446387 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Nucleotide

• Length: 180 bp

>T117745 NZ_CP035397:2446208-2446387 [Bacillus subtilis]
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG

Antitoxin

Nucleotide

• Length: 223 bp

>AT117745 NZ_CP035397:c2446533-2446311 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Structures

Toxin

• AlphaFold DB: A0A164X333

Antitoxin