Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 1793169..1793774 Replicon chromosome
Accession NZ_CP035382
Organism Leclercia adecarboxylata strain R25

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ES815_RS09580 Protein ID WP_142487604.1
Coordinates 1793460..1793774 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ES815_RS09575 Protein ID WP_142487603.1
Coordinates 1793169..1793459 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ES815_RS09560 1790669..1791571 + 903 WP_142487601.1 formate dehydrogenase subunit beta -
ES815_RS09565 1791568..1792203 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
ES815_RS09570 1792200..1793129 + 930 WP_142487602.1 formate dehydrogenase accessory protein FdhE -
ES815_RS09575 1793169..1793459 - 291 WP_142487603.1 helix-turn-helix domain-containing protein Antitoxin
ES815_RS09580 1793460..1793774 - 315 WP_142487604.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ES815_RS09585 1794003..1794929 + 927 WP_142487605.1 alpha/beta hydrolase -
ES815_RS09590 1795097..1795657 + 561 WP_142487606.1 Ail/Lom family outer membrane beta-barrel protein -
ES815_RS09595 1795724..1796665 - 942 WP_185902396.1 fatty acid biosynthesis protein FabY -
ES815_RS09600 1796710..1797147 - 438 WP_142487608.1 D-tyrosyl-tRNA(Tyr) deacylase -
ES815_RS09605 1797144..1798025 - 882 WP_142487609.1 virulence factor BrkB family protein -
ES815_RS09610 1798019..1798618 - 600 WP_142487610.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12219.20 Da        Isoelectric Point: 9.3249

>T117678 WP_142487604.1 NZ_CP035382:c1793774-1793460 [Leclercia adecarboxylata]
MLFIETDIFTEDVNKLLDDDEYHKLQVFLAMQPEYGDLIQNTGGLRKVRWLAGGKGGKRSGVRVIYFYRSRENEIRLVLI
YRKGIKDDLPANEKAVLKMIIERW

Download         Length: 315 bp

>T117678 NZ_CP035382:c1793774-1793460 [Leclercia adecarboxylata]
ATGCTATTCATTGAAACGGATATCTTCACTGAAGACGTCAATAAATTACTGGATGACGACGAATACCATAAACTGCAGGT
CTTTCTGGCAATGCAGCCTGAATATGGCGATCTGATTCAGAACACGGGAGGCTTACGCAAGGTTCGCTGGCTTGCTGGCG
GTAAGGGAGGAAAGCGTAGTGGTGTGCGAGTCATTTATTTTTATCGCTCACGTGAAAATGAAATTCGATTGGTGCTCATC
TATCGCAAAGGGATCAAGGATGACCTGCCAGCAAATGAGAAAGCCGTACTGAAAATGATTATTGAGAGATGGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10661.22 Da        Isoelectric Point: 11.0200

>AT117678 WP_142487603.1 NZ_CP035382:c1793459-1793169 [Leclercia adecarboxylata]
MDKALFERLTQSVAQMNEIAGGKREPSRTFQIDAMKIKEIRQASGLSQSKFAQLISVSVDTLRNWEQSRRSPTGPAKALL
RAIANDPQHVIPALSQ

Download         Length: 291 bp

>AT117678 NZ_CP035382:c1793459-1793169 [Leclercia adecarboxylata]
ATGGATAAGGCGCTATTTGAGCGGTTAACTCAAAGCGTGGCTCAGATGAACGAAATTGCCGGGGGCAAACGCGAGCCATC
GCGCACCTTTCAAATCGATGCCATGAAAATTAAAGAAATTCGTCAGGCGTCAGGGCTGTCGCAAAGTAAATTCGCGCAAC
TAATCTCGGTCAGTGTTGATACGCTACGCAACTGGGAGCAAAGTAGACGTTCACCTACAGGCCCGGCCAAGGCGCTACTT
CGTGCTATTGCCAACGATCCGCAGCATGTTATTCCTGCGCTATCCCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References