Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 765114..765825 Replicon chromosome
Accession NZ_CP035382
Organism Leclercia adecarboxylata strain R25

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ES815_RS04525 Protein ID WP_142486805.1
Coordinates 765114..765437 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ES815_RS04530 Protein ID WP_142486806.1
Coordinates 765481..765825 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ES815_RS04495 760661..761608 - 948 WP_142486799.1 LysR family transcriptional regulator -
ES815_RS04500 761709..762143 + 435 WP_142486800.1 DMT family transporter -
ES815_RS04505 762148..762624 + 477 WP_142486801.1 DMT family transporter -
ES815_RS04510 762768..763454 + 687 WP_142486802.1 RluA family pseudouridine synthase -
ES815_RS04515 763477..763860 - 384 WP_142486803.1 VOC family protein -
ES815_RS04520 764008..764901 + 894 WP_142486804.1 PhzF family phenazine biosynthesis protein -
ES815_RS04525 765114..765437 + 324 WP_142486805.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ES815_RS04530 765481..765825 + 345 WP_142486806.1 HigA family addiction module antidote protein Antitoxin
ES815_RS04535 765901..766251 - 351 WP_142486807.1 type II toxin-antitoxin system HicB family antitoxin -
ES815_RS04540 766244..766522 - 279 WP_142486808.1 type II toxin-antitoxin system HicA family toxin -
ES815_RS23730 766684..766945 + 262 Protein_684 ash family protein -
ES815_RS04545 766971..767407 + 437 Protein_685 hypothetical protein -
ES815_RS04550 767469..768032 + 564 WP_142486809.1 hypothetical protein -
ES815_RS23735 768113..768286 + 174 WP_166183533.1 hypothetical protein -
ES815_RS04555 768351..768869 - 519 WP_142486810.1 hypothetical protein -
ES815_RS04560 769455..769640 + 186 WP_103180815.1 general stress protein -
ES815_RS04565 769733..770227 + 495 WP_106994953.1 ferritin-like domain-containing protein -
ES815_RS04570 770259..770765 + 507 WP_142486811.1 ferritin-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(10-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-71)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12253.19 Da        Isoelectric Point: 10.1298

>T117675 WP_142486805.1 NZ_CP035382:765114-765437 [Leclercia adecarboxylata]
MTTPLTLRSISDFRDTWLEDFFLYGRPHGKIPAEIASALMRKLDIINAATSYRDLRSPPGNKLEALSSPLLGCYLIRVNR
QYRLIFIWSGGKAKGIYLDPHTYNAHR

Download         Length: 324 bp

>T117675 NZ_CP035382:765114-765437 [Leclercia adecarboxylata]
ATGACCACACCACTTACGTTAAGGAGCATCTCTGACTTTCGCGATACCTGGCTTGAGGACTTTTTTCTATATGGACGTCC
ACATGGAAAAATCCCGGCAGAGATAGCGTCAGCTCTGATGCGAAAACTCGACATCATCAACGCAGCGACCTCGTATCGGG
ATCTGCGTAGCCCACCCGGCAACAAGCTTGAAGCGTTGAGCTCGCCGCTTCTGGGTTGTTATTTGATACGCGTGAACAGG
CAATACCGACTGATTTTCATCTGGTCAGGCGGTAAGGCGAAAGGGATTTATCTTGATCCTCATACCTACAATGCTCACCG
ATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13134.04 Da        Isoelectric Point: 6.3288

>AT117675 WP_142486806.1 NZ_CP035382:765481-765825 [Leclercia adecarboxylata]
MAFTNSTRKPTTPGDILLHEFLEPLHLKIADLAEMLNVHRNSVSALVNNNRKLTTDMAVRLARAFDTTIEFWLNLQLNVD
IWEIQHDERMQAEHQQIITAAEMVERKKAQQSVA

Download         Length: 345 bp

>AT117675 NZ_CP035382:765481-765825 [Leclercia adecarboxylata]
ATGGCATTCACAAACAGCACCCGTAAACCGACCACACCCGGCGATATTCTGCTTCACGAGTTTCTTGAGCCGCTGCATTT
AAAAATTGCCGATCTGGCCGAGATGCTTAACGTGCACAGAAACAGCGTCAGCGCGCTGGTCAATAACAACCGAAAACTGA
CCACGGACATGGCCGTACGGCTAGCCCGGGCTTTTGATACCACCATTGAGTTTTGGCTGAACTTGCAGCTGAACGTGGAT
ATCTGGGAAATTCAGCACGACGAGCGCATGCAGGCAGAACATCAGCAGATCATTACTGCGGCGGAGATGGTTGAGAGGAA
GAAAGCGCAGCAGTCTGTAGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References