117664

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2454281..2454798 Replicon chromosome
Accession NZ_CP035369
Organism Staphylococcus aureus strain LAC

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag ERW10_RS12795 Protein ID WP_000113262.1
Coordinates 2454532..2454798 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag ERW10_RS12790 Protein ID WP_000584502.1
Coordinates 2454281..2454532 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ERW10_RS12760 2449982..2450701 + 720 WP_000479576.1 amino acid ABC transporter permease -
ERW10_RS12765 2450698..2451429 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
ERW10_RS12770 2451526..2452776 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
ERW10_RS12775 2453031..2453390 + 360 WP_000819847.1 DUF4467 domain-containing protein -
ERW10_RS12780 2453409..2454008 + 600 WP_000162813.1 DsbA family protein -
ERW10_RS12785 2454015..2454116 + 102 WP_001791744.1 hypothetical protein -
ERW10_RS12790 2454281..2454532 + 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ERW10_RS12795 2454532..2454798 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
ERW10_RS12800 2454833..2454904 + 72 Protein_2360 hypothetical protein -
ERW10_RS12805 2455093..2456643 + 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
ERW10_RS12810 2456829..2457296 + 468 WP_000153344.1 SRPBCC domain-containing protein -
ERW10_RS12815 2457380..2457562 + 183 WP_000230294.1 hypothetical protein -
ERW10_RS12820 2457779..2458603 + 825 WP_000572040.1 formate/nitrite transporter family protein -
ERW10_RS12825 2458836..2459372 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T117664 WP_000113262.1 NZ_CP035369:2454532-2454798 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T117664 NZ_CP035369:2454532-2454798 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT117664 WP_000584502.1 NZ_CP035369:2454281-2454532 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT117664 NZ_CP035369:2454281-2454532 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGTTATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References