Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2397427..2397950 Replicon chromosome
Accession NZ_CP035369
Organism Staphylococcus aureus strain LAC

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag ERW10_RS12475 Protein ID WP_000074048.1
Coordinates 2397684..2397950 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag ERW10_RS12470 Protein ID WP_000587616.1
Coordinates 2397427..2397684 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ERW10_RS12445 2392507..2393700 + 1194 WP_000675401.1 MFS transporter -
ERW10_RS12450 2393924..2394673 - 750 WP_000072444.1 hypothetical protein -
ERW10_RS12455 2394868..2396445 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
ERW10_RS12460 2396613..2397068 - 456 WP_000732082.1 DUF1307 domain-containing protein -
ERW10_RS12465 2397127..2397321 + 195 WP_001790145.1 hypothetical protein -
ERW10_RS12470 2397427..2397684 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ERW10_RS12475 2397684..2397950 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
ERW10_RS12480 2398305..2399381 + 1077 WP_001076671.1 M42 family metallopeptidase -
ERW10_RS12485 2399629..2400291 + 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
ERW10_RS12490 2400284..2401060 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
ERW10_RS12495 2401456..2402643 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T117661 WP_000074048.1 NZ_CP035369:2397684-2397950 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T117661 NZ_CP035369:2397684-2397950 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT117661 WP_000587616.1 NZ_CP035369:2397427-2397684 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT117661 NZ_CP035369:2397427-2397684 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References