Detailed information of TA system TA117646

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-symR/Ldr(toxin)
• Location: 4419931..4420152
• Replicon: chromosome
• Accession: NZ_CP035366
• Organism: Escherichia coli O157:H7 strain C1-057

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: ES669_RS22845
• Protein ID: WP_001295224.1
• Coordinates: 4419931..4420038 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	4420087..4420152 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ES669_RS22820	4415184..4415936	-	753	Protein_4336	cellulose biosynthesis protein BcsQ	-
ES669_RS22825	4415948..4416136	-	189	WP_001063316.1	YhjR family protein	-
ES669_RS22830	4416409..4417980	+	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
ES669_RS22835	4417977..4418168	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
ES669_RS22840	4418165..4419844	+	1680	WP_000191592.1	cellulose biosynthesis protein BcsG	-
ES669_RS22845	4419931..4420038	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4420087..4420152	+	66	NuclAT_16	-	Antitoxin
-	4420087..4420152	+	66	NuclAT_16	-	Antitoxin
-	4420087..4420152	+	66	NuclAT_16	-	Antitoxin
-	4420087..4420152	+	66	NuclAT_16	-	Antitoxin
-	4420087..4420152	+	66	NuclAT_21	-	Antitoxin
-	4420087..4420152	+	66	NuclAT_21	-	Antitoxin
-	4420087..4420152	+	66	NuclAT_21	-	Antitoxin
-	4420087..4420152	+	66	NuclAT_21	-	Antitoxin
ES669_RS22850	4420514..4421785	+	1272	WP_001301684.1	amino acid permease	-
ES669_RS22855	4421815..4422819	-	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
ES669_RS22860	4422816..4423799	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
ES669_RS22865	4423810..4424712	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T117646 WP_001295224.1 NZ_CP035366:c4420038-4419931 [Escherichia coli O157:H7]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T117646 NZ_CP035366:c4420038-4419931 [Escherichia coli O157:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT117646 NZ_CP035366:4420087-4420152 [Escherichia coli O157:H7]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin