117629

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2191065..2191536 Replicon chromosome
Accession NZ_CP035366
Organism Escherichia coli O157:H7 strain C1-057

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag ES669_RS11395 Protein ID WP_001303511.1
Coordinates 2191258..2191536 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag ES669_RS11390 Protein ID WP_001302048.1
Coordinates 2191065..2191256 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ES669_RS11350 2186272..2186856 - 585 WP_000206793.1 DUF551 domain-containing protein -
ES669_RS11355 2186913..2187308 - 396 WP_001118159.1 DUF977 family protein -
ES669_RS11360 2187324..2188093 - 770 Protein_2150 DUF1627 domain-containing protein -
ES669_RS11365 2188119..2188859 - 741 WP_000788936.1 ATP-binding protein -
ES669_RS11370 2188866..2189828 - 963 WP_000095670.1 helix-turn-helix domain-containing protein -
ES669_RS11375 2189851..2190276 - 426 WP_000693943.1 Rha family transcriptional regulator -
ES669_RS11380 2190273..2190575 - 303 WP_000172738.1 transcriptional regulator -
ES669_RS11385 2190673..2191044 + 372 WP_001169686.1 hypothetical protein -
ES669_RS11390 2191065..2191256 + 192 WP_001302048.1 hypothetical protein Antitoxin
ES669_RS11395 2191258..2191536 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ES669_RS11400 2191889..2192188 + 300 WP_001240334.1 hypothetical protein -
ES669_RS11405 2192260..2192478 + 219 WP_001171930.1 hypothetical protein -
ES669_RS11415 2193047..2193235 + 189 WP_000449192.1 cell division inhibition protein DicB -
ES669_RS11420 2193232..2193423 + 192 WP_001090200.1 DUF1482 family protein -
ES669_RS11425 2193516..2195987 + 2472 WP_000048458.1 exonuclease -
ES669_RS11430 2196060..2196311 + 252 WP_000005552.1 excisionase family protein -
ES669_RS11435 2196346..2196530 + 185 Protein_2164 DUF3596 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - nleG7' 2100765..2198697 97932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T117629 WP_001303511.1 NZ_CP035366:2191258-2191536 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T117629 NZ_CP035366:2191258-2191536 [Escherichia coli O157:H7]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT117629 WP_001302048.1 NZ_CP035366:2191065-2191256 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT117629 NZ_CP035366:2191065-2191256 [Escherichia coli O157:H7]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References