Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1159756..1160278 Replicon chromosome
Accession NZ_CP035309
Organism Macrococcus canis strain KM0218

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag EST43_RS05845 Protein ID WP_138071160.1
Coordinates 1159756..1160028 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag EST43_RS05850 Protein ID WP_138071162.1
Coordinates 1160021..1160278 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EST43_RS05815 1154834..1156081 + 1248 WP_138071149.1 putative DNA binding domain-containing protein -
EST43_RS05820 1156126..1156572 - 447 WP_158290696.1 GNAT family N-acetyltransferase -
EST43_RS05825 1156654..1157394 + 741 WP_138071153.1 hypothetical protein -
EST43_RS05830 1157404..1158294 + 891 WP_138071155.1 phosphotransferase -
EST43_RS05835 1158480..1158965 + 486 WP_138071156.1 NUDIX domain-containing protein -
EST43_RS05840 1158971..1159738 + 768 WP_138071158.1 hypothetical protein -
EST43_RS05845 1159756..1160028 - 273 WP_138071160.1 Txe/YoeB family addiction module toxin Toxin
EST43_RS05850 1160021..1160278 - 258 WP_138071162.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EST43_RS05855 1160567..1160791 + 225 WP_138071164.1 toxin-antitoxin system, antitoxin component -
EST43_RS05860 1160788..1161054 + 267 WP_138071166.1 type II toxin-antitoxin system RelE/ParE family toxin -
EST43_RS05865 1161157..1161651 + 495 WP_158290697.1 hypothetical protein -
EST43_RS05870 1161812..1163029 + 1218 WP_138071170.1 ATP-binding protein -
EST43_RS05875 1163165..1164427 + 1263 WP_138072992.1 Y-family DNA polymerase -
EST43_RS05880 1164571..1164759 + 189 WP_096076537.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10684.42 Da        Isoelectric Point: 9.7524

>T117578 WP_138071160.1 NZ_CP035309:c1160028-1159756 [Macrococcus canis]
MTKKKILFYSSGFEDYTYWQTNDKTVLKKINKLIKSIMIDGANEGIGKPEKLLGNYTGCYSRRITHEHRLVYKIDDDSIC
ILQCRFHYKR

Download         Length: 273 bp

>T117578 NZ_CP035309:c1160028-1159756 [Macrococcus canis]
ATGACTAAGAAAAAGATACTATTTTATTCAAGTGGTTTTGAAGATTATACGTACTGGCAAACTAACGATAAAACTGTATT
AAAGAAAATAAATAAACTAATAAAGAGTATTATGATTGATGGTGCAAATGAAGGTATAGGTAAGCCAGAAAAATTATTAG
GAAACTATACAGGTTGCTATAGCAGAAGGATCACTCATGAACATAGGCTCGTATATAAGATAGATGATGATTCAATATGT
ATTTTACAATGTCGTTTTCATTATAAAAGGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9753.81 Da        Isoelectric Point: 4.0808

>AT117578 WP_138071162.1 NZ_CP035309:c1160278-1160021 [Macrococcus canis]
MKVTTYSNARSNFRKIIDIVNEDCEPYTITTNTHNAVILSEQDYNSMIETLYLQSTPANAERLQKAIDESIDKNNLLQVE
IDLDD

Download         Length: 258 bp

>AT117578 NZ_CP035309:c1160278-1160021 [Macrococcus canis]
ATGAAAGTCACAACTTATTCTAATGCAAGATCAAATTTTAGAAAAATAATAGATATTGTTAATGAAGACTGTGAACCTTA
CACAATCACAACAAATACGCATAATGCCGTGATATTATCTGAACAAGATTATAATAGTATGATTGAAACACTTTATTTAC
AGAGTACACCAGCGAATGCCGAAAGGTTACAAAAAGCGATTGATGAATCAATTGATAAAAATAACTTACTTCAAGTTGAG
ATTGATTTAGATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References