Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1427225..1427808 Replicon chromosome
Accession NZ_CP035284
Organism Paracoccus versutus strain UW1

Toxin (Protein)


Gene name graT Uniprot ID A0A3E0BZ42
Locus tag EQ718_RS07135 Protein ID WP_036749952.1
Coordinates 1427225..1427506 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EQ718_RS07140 Protein ID WP_036749954.1
Coordinates 1427518..1427808 (+) Length 97 a.a.

Genomic Context

EQ718_RS07105EQ718_RS07135EQ718_RS07140EQ718_RS07150EQ718_RS07155EQ718_RS07160EQ718_RS07165EQ718_RS07170EQ718_RS07095EQ718_RS07100EQ718_RS07115EQ718_RS07120EQ718_RS07125EQ718_RS07130EQ718_RS07145EQ718_RS07175EQ718_RS07180
Location: 1423980..1425077 (1098 bp)
Type: Others
Protein ID: WP_036749941.1
Location: 1427225..1427506 (282 bp)
Type: Toxin
Protein ID: WP_036749952.1
Location: 1427518..1427808 (291 bp)
Type: Antitoxin
Protein ID: WP_036749954.1
Location: 1428794..1428952 (159 bp)
Type: Others
Protein ID: WP_157034045.1
Location: 1428949..1429314 (366 bp)
Type: Others
Protein ID: WP_036749963.1
Location: 1429398..1429913 (516 bp)
Type: Others
Protein ID: WP_036749966.1
Location: 1430155..1430547 (393 bp)
Type: Others
Protein ID: WP_036749968.1
Location: 1430740..1431105 (366 bp)
Type: Others
Protein ID: WP_036749970.1
Location: 1422325..1422942 (618 bp)
Type: Others
Protein ID: WP_036749936.1
Location: 1423056..1423853 (798 bp)
Type: Others
Protein ID: WP_036749939.1
Location: 1425819..1426211 (393 bp)
Type: Others
Protein ID: WP_036749944.1
Location: 1426270..1426464 (195 bp)
Type: Others
Protein ID: Protein_1401
Location: 1426467..1426763 (297 bp)
Type: Others
Protein ID: WP_036749947.1
Location: 1426874..1427062 (189 bp)
Type: Others
Protein ID: WP_036749949.1
Location: 1428010..1428393 (384 bp)
Type: Others
Protein ID: WP_036749957.1
Location: 1431163..1431363 (201 bp)
Type: Others
Protein ID: WP_036749972.1
Location: 1431427..1431798 (372 bp)
Type: Others
Protein ID: WP_036749973.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EQ718_RS07095 (EQ718_07045)1422325..1422942-618WP_036749936.1glutathione S-transferase N-terminal domain-containing protein-
EQ718_RS07100 (EQ718_07050)1423056..1423853-798WP_036749939.1tryptophan synthase subunit alpha-
EQ718_RS07105 (EQ718_07055)1423980..1425077+1098WP_036749941.1redox-regulated ATPase YchF-
EQ718_RS07115 (EQ718_07065)1425819..1426211-393WP_036749944.1transposase domain-containing protein-
EQ718_RS07120 (EQ718_07070)1426270..1426464-195Protein_1401putative addiction module antidote protein-
EQ718_RS07125 (EQ718_07075)1426467..1426763-297WP_036749947.1type II toxin-antitoxin system RelE/ParE family toxin-
EQ718_RS07130 (EQ718_07080)1426874..1427062-189WP_036749949.1hypothetical protein-
EQ718_RS07135 (EQ718_07085)1427225..1427506+282WP_036749952.1type II toxin-antitoxin system RelE/ParE family toxinToxin
EQ718_RS07140 (EQ718_07090)1427518..1427808+291WP_036749954.1HigA family addiction module antitoxinAntitoxin
EQ718_RS07145 (EQ718_07095)1428010..1428393-384WP_036749957.1DoxX family protein-
EQ718_RS071501428794..1428952+159WP_157034045.1hypothetical protein-
EQ718_RS07155 (EQ718_07105)1428949..1429314+366WP_036749963.1helix-turn-helix domain-containing protein-
EQ718_RS07160 (EQ718_07110)1429398..1429913+516WP_036749966.1hypothetical protein-
EQ718_RS07165 (EQ718_07115)1430155..1430547+393WP_036749968.1hypothetical protein-
EQ718_RS07170 (EQ718_07120)1430740..1431105+366WP_036749970.1DUF983 domain-containing protein-
EQ718_RS07175 (EQ718_07125)1431163..1431363-201WP_036749972.1hypothetical protein-
EQ718_RS07180 (EQ718_07130)1431427..1431798-372WP_036749973.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(16-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-79)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10211.77 Da        Isoelectric Point: 9.9427

>T117542 WP_036749952.1 NZ_CP035284:1427225-1427506 [Paracoccus versutus]
MIQSIRGELTAQVLAGKPGKGFPANLSKIAVRKVAMLQAAHVLDDLRAPPANRLEALKGDRAGQHSIRVNDPWRICFTWT
QNGPADVEIVDYH

Download         Length: 282 bp

>T117542 NZ_CP035284:1427225-1427506 [Paracoccus versutus]
ATGATACAGAGCATCAGAGGCGAGTTGACCGCGCAGGTCCTGGCTGGCAAGCCGGGCAAGGGCTTTCCCGCCAACCTGTC
CAAGATCGCCGTCCGCAAGGTGGCGATGCTGCAAGCGGCTCACGTCCTGGACGACCTGCGGGCGCCCCCGGCGAACCGGC
TGGAAGCCCTCAAGGGCGATAGGGCGGGCCAGCATTCGATCCGGGTCAACGACCCGTGGCGCATCTGTTTCACCTGGACC
CAGAACGGCCCTGCCGATGTCGAAATCGTGGACTACCACTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10691.34 Da        Isoelectric Point: 4.8000

>AT117542 WP_036749954.1 NZ_CP035284:1427518-1427808 [Paracoccus versutus]
MTMLQVPVHPGEILKEEFLDELGISAGKLARHVHVPRTRIERLVKEETAMTVDTAQRLAKALGTSVEFWMNLQLNYDLIT
NTPDPDVADIQPLAAA

Download         Length: 291 bp

>AT117542 NZ_CP035284:1427518-1427808 [Paracoccus versutus]
ATGACCATGCTGCAAGTGCCGGTCCATCCCGGCGAAATCCTGAAGGAAGAATTCCTGGACGAGTTGGGGATCAGCGCCGG
CAAGCTGGCCCGGCATGTCCATGTGCCCCGCACCCGCATCGAGCGCCTGGTGAAGGAAGAAACCGCCATGACCGTGGACA
CGGCGCAGCGGCTCGCCAAGGCTCTGGGAACCTCGGTGGAGTTCTGGATGAACCTTCAGCTGAACTACGACCTGATTACG
AACACGCCAGATCCAGACGTGGCCGATATCCAGCCGCTGGCAGCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A3E0BZ42

Antitoxin

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Source
ID
Structure
No matching records found

References