117515

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1596794..1597306 Replicon chromosome
Accession NZ_CP035265
Organism Streptococcus pneumoniae strain TVO_1901920

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag EQH15_RS08080 Protein ID WP_000924721.1
Coordinates 1596794..1597048 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag EQH15_RS08085 Protein ID WP_000388572.1
Coordinates 1597052..1597306 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH15_RS08065 (EQH15_08475) 1593895..1594209 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
EQH15_RS08070 (EQH15_08480) 1594234..1594860 - 627 WP_000775037.1 guanylate kinase -
EQH15_RS08075 (EQH15_08485) 1594990..1596603 - 1614 WP_000404940.1 ribonuclease Y -
EQH15_RS08080 (EQH15_08490) 1596794..1597048 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
EQH15_RS08085 (EQH15_08495) 1597052..1597306 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EQH15_RS08090 (EQH15_08500) 1597544..1598641 - 1098 WP_000156355.1 nucleotidyltransferase -
EQH15_RS08095 (EQH15_08505) 1598651..1599397 - 747 WP_000605157.1 class I SAM-dependent methyltransferase -
EQH15_RS08100 (EQH15_08510) 1599500..1599853 - 354 WP_001003001.1 ribosome silencing factor -
EQH15_RS08105 (EQH15_08515) 1599866..1600366 - 501 WP_000844717.1 cysteine hydrolase family protein -
EQH15_RS08110 (EQH15_08520) 1600367..1600960 - 594 WP_000121648.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
EQH15_RS08115 (EQH15_08525) 1600960..1601589 - 630 WP_000151313.1 nicotinate-nucleotide adenylyltransferase -
EQH15_RS08120 (EQH15_08530) 1601641..1601952 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T117515 WP_000924721.1 NZ_CP035265:c1597048-1596794 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T117515 NZ_CP035265:c1597048-1596794 [Streptococcus pneumoniae]
ATGCTACTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT117515 WP_000388572.1 NZ_CP035265:c1597306-1597052 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT117515 NZ_CP035265:c1597306-1597052 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCCCAAAATAAGGAGTTATCAGACAAGGTTTTACGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGGTCCAT
GTGATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References