Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1633399..1633911 Replicon chromosome
Accession NZ_CP035264
Organism Streptococcus pneumoniae strain TVO_1901921

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag EQH16_RS08350 Protein ID WP_000924721.1
Coordinates 1633399..1633653 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag EQH16_RS08355 Protein ID WP_000388572.1
Coordinates 1633657..1633911 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH16_RS08335 (EQH16_08745) 1630500..1630814 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
EQH16_RS08340 (EQH16_08750) 1630839..1631465 - 627 WP_000775037.1 guanylate kinase -
EQH16_RS08345 (EQH16_08755) 1631595..1633208 - 1614 WP_000404940.1 ribonuclease Y -
EQH16_RS08350 (EQH16_08760) 1633399..1633653 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
EQH16_RS08355 (EQH16_08765) 1633657..1633911 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EQH16_RS08360 (EQH16_08770) 1634149..1635246 - 1098 WP_000156355.1 nucleotidyltransferase -
EQH16_RS08365 (EQH16_08775) 1635256..1636002 - 747 WP_000605157.1 class I SAM-dependent methyltransferase -
EQH16_RS08370 (EQH16_08780) 1636105..1636458 - 354 WP_001003001.1 ribosome silencing factor -
EQH16_RS08375 (EQH16_08785) 1636471..1636971 - 501 WP_000844717.1 cysteine hydrolase family protein -
EQH16_RS08380 (EQH16_08790) 1636972..1637565 - 594 WP_000121648.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
EQH16_RS08385 (EQH16_08795) 1637565..1638194 - 630 WP_000151313.1 nicotinate-nucleotide adenylyltransferase -
EQH16_RS08390 (EQH16_08800) 1638246..1638557 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T117510 WP_000924721.1 NZ_CP035264:c1633653-1633399 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T117510 NZ_CP035264:c1633653-1633399 [Streptococcus pneumoniae]
ATGCTACTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT117510 WP_000388572.1 NZ_CP035264:c1633911-1633657 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT117510 NZ_CP035264:c1633911-1633657 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCCCAAAATAAGGAGTTATCAGACAAGGTTTTACGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGGTCCAT
GTGATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References