Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1600964..1601476 Replicon chromosome
Accession NZ_CP035263
Organism Streptococcus pneumoniae strain TVO_1901922

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag EQH17_RS07860 Protein ID WP_000924721.1
Coordinates 1600964..1601218 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag EQH17_RS07865 Protein ID WP_000388572.1
Coordinates 1601222..1601476 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH17_RS07845 (EQH17_08320) 1598065..1598379 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
EQH17_RS07850 (EQH17_08325) 1598404..1599030 - 627 WP_000775037.1 guanylate kinase -
EQH17_RS07855 (EQH17_08330) 1599160..1600773 - 1614 WP_000404940.1 ribonuclease Y -
EQH17_RS07860 (EQH17_08335) 1600964..1601218 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
EQH17_RS07865 (EQH17_08340) 1601222..1601476 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EQH17_RS07870 (EQH17_08345) 1601714..1602811 - 1098 WP_000156330.1 nucleotidyltransferase -
EQH17_RS07875 (EQH17_08350) 1602821..1603567 - 747 WP_000605157.1 class I SAM-dependent methyltransferase -
EQH17_RS07880 (EQH17_08355) 1603670..1604023 - 354 WP_001003001.1 ribosome silencing factor -
EQH17_RS07885 (EQH17_08360) 1604036..1604536 - 501 WP_000844713.1 cysteine hydrolase family protein -
EQH17_RS07890 (EQH17_08365) 1604537..1605130 - 594 WP_000121651.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
EQH17_RS07895 (EQH17_08370) 1605130..1605759 - 630 WP_000151313.1 nicotinate-nucleotide adenylyltransferase -
EQH17_RS07900 (EQH17_08375) 1605811..1606122 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T117505 WP_000924721.1 NZ_CP035263:c1601218-1600964 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T117505 NZ_CP035263:c1601218-1600964 [Streptococcus pneumoniae]
ATGCTGCTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAATCAGGATAAGAAAACGTTAAAAAGAAT
CAATAAACTAATCAAGGATATTCAACGTGATCCCTTTACAGGAATAGGTAAACCAGAACCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT117505 WP_000388572.1 NZ_CP035263:c1601476-1601222 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT117505 NZ_CP035263:c1601476-1601222 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTCCTTTCAAAGAGTGAGTGGGATAGTATCCAAGAAACCCTGA
GAATTGCTCAAAATAAGGAACTTTCTGATAAGGTTTTGCGAGGAATGGCTCAAGTTCGTGCTGGAAGTACTCAGGTCCAT
GTTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References