117497

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1610761..1611273 Replicon chromosome
Accession NZ_CP035261
Organism Streptococcus pneumoniae strain TVO_1901924

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag EQH19_RS08060 Protein ID WP_000924721.1
Coordinates 1610761..1611015 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B7LSG7
Locus tag EQH19_RS08065 Protein ID WP_000388571.1
Coordinates 1611019..1611273 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH19_RS08045 (EQH19_08530) 1607862..1608176 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
EQH19_RS08050 (EQH19_08535) 1608201..1608827 - 627 WP_000775047.1 guanylate kinase -
EQH19_RS08055 (EQH19_08540) 1608957..1610570 - 1614 WP_000404940.1 ribonuclease Y -
EQH19_RS08060 (EQH19_08545) 1610761..1611015 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
EQH19_RS08065 (EQH19_08550) 1611019..1611273 - 255 WP_000388571.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EQH19_RS08070 (EQH19_08555) 1611511..1612608 - 1098 WP_000156345.1 nucleotidyltransferase -
EQH19_RS08075 (EQH19_08560) 1612618..1613364 - 747 WP_000605154.1 class I SAM-dependent methyltransferase -
EQH19_RS08080 (EQH19_08565) 1613467..1613820 - 354 WP_001003001.1 ribosome silencing factor -
EQH19_RS08085 (EQH19_08570) 1613833..1614333 - 501 WP_000844707.1 cysteine hydrolase family protein -
EQH19_RS08090 (EQH19_08575) 1614334..1614927 - 594 WP_000121654.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
EQH19_RS08095 (EQH19_08580) 1614927..1615556 - 630 WP_000151307.1 nicotinate-nucleotide adenylyltransferase -
EQH19_RS08100 (EQH19_08585) 1615608..1615919 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T117497 WP_000924721.1 NZ_CP035261:c1611015-1610761 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T117497 NZ_CP035261:c1611015-1610761 [Streptococcus pneumoniae]
ATGCTACTCAAGTTTACAGAAGATGCGTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9718.05 Da        Isoelectric Point: 4.8430

>AT117497 WP_000388571.1 NZ_CP035261:c1611273-1611019 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSIQVH
VIEE

Download         Length: 255 bp

>AT117497 NZ_CP035261:c1611273-1611019 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCTCAAAATAAGGAGTTATCAGACAAGGTTTTGCGAGGAATGGCTCAAGTCCGTGCTGGAAGCATTCAGGTCCAT
GTGATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB A0A0B7LSG7

References