Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1671524..1672036 Replicon chromosome
Accession NZ_CP035257
Organism Streptococcus pneumoniae strain TVO_1901928

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag EQH23_RS08400 Protein ID WP_000924721.1
Coordinates 1671524..1671778 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag EQH23_RS08405 Protein ID WP_000388572.1
Coordinates 1671782..1672036 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH23_RS08385 (EQH23_08875) 1668625..1668939 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
EQH23_RS08390 (EQH23_08880) 1668964..1669590 - 627 WP_000775037.1 guanylate kinase -
EQH23_RS08395 (EQH23_08885) 1669720..1671333 - 1614 WP_000404929.1 ribonuclease Y -
EQH23_RS08400 (EQH23_08890) 1671524..1671778 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
EQH23_RS08405 (EQH23_08895) 1671782..1672036 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EQH23_RS08410 (EQH23_08900) 1672274..1673371 - 1098 WP_000156323.1 nucleotidyltransferase -
EQH23_RS08415 (EQH23_08905) 1673395..1675206 - 1812 WP_001025033.1 NACHT domain-containing protein -
EQH23_RS08420 (EQH23_08910) 1675247..1675987 - 741 WP_000257068.1 class I SAM-dependent methyltransferase -
EQH23_RS08425 (EQH23_08915) 1676307..1676660 - 354 WP_001003001.1 ribosome silencing factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T117485 WP_000924721.1 NZ_CP035257:c1671778-1671524 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T117485 NZ_CP035257:c1671778-1671524 [Streptococcus pneumoniae]
ATGCTACTCAAGTTTACAGAAGATGCGTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT117485 WP_000388572.1 NZ_CP035257:c1672036-1671782 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT117485 NZ_CP035257:c1672036-1671782 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCCCAAAATAAGGAGTTATCAGACAAGGTTTTGCGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGGTCCAT
GTGATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References