117465

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1564663..1565175 Replicon chromosome
Accession NZ_CP035247
Organism Streptococcus pneumoniae strain TVO_1901940

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag EQH33_RS07765 Protein ID WP_000924721.1
Coordinates 1564663..1564917 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B7LSG7
Locus tag EQH33_RS07770 Protein ID WP_000388571.1
Coordinates 1564921..1565175 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH33_RS07750 (EQH33_08225) 1561764..1562078 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
EQH33_RS07755 (EQH33_08230) 1562103..1562729 - 627 WP_000775037.1 guanylate kinase -
EQH33_RS07760 (EQH33_08235) 1562859..1564472 - 1614 WP_000404940.1 ribonuclease Y -
EQH33_RS07765 (EQH33_08240) 1564663..1564917 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
EQH33_RS07770 (EQH33_08245) 1564921..1565175 - 255 WP_000388571.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EQH33_RS07775 (EQH33_08250) 1565413..1566510 - 1098 WP_000156357.1 nucleotidyltransferase -
EQH33_RS07780 (EQH33_08255) 1566520..1567266 - 747 WP_000605159.1 class I SAM-dependent methyltransferase -
EQH33_RS07785 (EQH33_08260) 1567369..1567722 - 354 WP_001003001.1 ribosome silencing factor -
EQH33_RS07790 (EQH33_08265) 1567735..1568235 - 501 WP_000844721.1 cysteine hydrolase family protein -
EQH33_RS07795 (EQH33_08270) 1568236..1568829 - 594 WP_000331232.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
EQH33_RS07800 (EQH33_08275) 1568829..1569458 - 630 WP_000151306.1 nicotinate-nucleotide adenylyltransferase -
EQH33_RS07805 (EQH33_08280) 1569510..1569821 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T117465 WP_000924721.1 NZ_CP035247:c1564917-1564663 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T117465 NZ_CP035247:c1564917-1564663 [Streptococcus pneumoniae]
ATGCTACTCAAGTTTACAGAAGATGCGTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9718.05 Da        Isoelectric Point: 4.8430

>AT117465 WP_000388571.1 NZ_CP035247:c1565175-1564921 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSIQVH
VIEE

Download         Length: 255 bp

>AT117465 NZ_CP035247:c1565175-1564921 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCTCAAAATAAGGAGTTATCAGACAAGGTTTTGCGAGGAATGGCTCAAGTCCGTGCTGGAAGCATTCAGGTCCAT
GTGATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB A0A0B7LSG7

References