Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1564714..1565226 Replicon chromosome
Accession NZ_CP035246
Organism Streptococcus pneumoniae strain TVO_1901941

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag EQH34_RS07760 Protein ID WP_000924721.1
Coordinates 1564714..1564968 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B7LSG7
Locus tag EQH34_RS07765 Protein ID WP_000388571.1
Coordinates 1564972..1565226 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH34_RS07745 (EQH34_08220) 1561815..1562129 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
EQH34_RS07750 (EQH34_08225) 1562154..1562780 - 627 WP_000775037.1 guanylate kinase -
EQH34_RS07755 (EQH34_08230) 1562910..1564523 - 1614 WP_000404940.1 ribonuclease Y -
EQH34_RS07760 (EQH34_08235) 1564714..1564968 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
EQH34_RS07765 (EQH34_08240) 1564972..1565226 - 255 WP_000388571.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EQH34_RS07770 (EQH34_08245) 1565464..1566561 - 1098 WP_000156357.1 nucleotidyltransferase -
EQH34_RS07775 (EQH34_08250) 1566571..1567317 - 747 WP_000605159.1 class I SAM-dependent methyltransferase -
EQH34_RS07780 (EQH34_08255) 1567420..1567773 - 354 WP_001003001.1 ribosome silencing factor -
EQH34_RS07785 (EQH34_08260) 1567786..1568286 - 501 WP_000844721.1 cysteine hydrolase family protein -
EQH34_RS07790 (EQH34_08265) 1568287..1568880 - 594 WP_000331232.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
EQH34_RS07795 (EQH34_08270) 1568880..1569509 - 630 WP_000151306.1 nicotinate-nucleotide adenylyltransferase -
EQH34_RS07800 (EQH34_08275) 1569561..1569872 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T117462 WP_000924721.1 NZ_CP035246:c1564968-1564714 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T117462 NZ_CP035246:c1564968-1564714 [Streptococcus pneumoniae]
ATGCTACTCAAGTTTACAGAAGATGCGTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9718.05 Da        Isoelectric Point: 4.8430

>AT117462 WP_000388571.1 NZ_CP035246:c1565226-1564972 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSIQVH
VIEE

Download         Length: 255 bp

>AT117462 NZ_CP035246:c1565226-1564972 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCTCAAAATAAGGAGTTATCAGACAAGGTTTTGCGAGGAATGGCTCAAGTCCGTGCTGGAAGCATTCAGGTCCAT
GTGATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB A0A0B7LSG7

References