Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1521934..1522446 Replicon chromosome
Accession NZ_CP035241
Organism Streptococcus pneumoniae strain TVO_1901948

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag EQH39_RS07565 Protein ID WP_000924721.1
Coordinates 1521934..1522188 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B7LSG7
Locus tag EQH39_RS07570 Protein ID WP_000388571.1
Coordinates 1522192..1522446 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH39_RS07550 (EQH39_07970) 1519035..1519349 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
EQH39_RS07555 (EQH39_07975) 1519374..1520000 - 627 WP_000775037.1 guanylate kinase -
EQH39_RS07560 (EQH39_07980) 1520130..1521743 - 1614 WP_000404940.1 ribonuclease Y -
EQH39_RS07565 (EQH39_07985) 1521934..1522188 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
EQH39_RS07570 (EQH39_07990) 1522192..1522446 - 255 WP_000388571.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EQH39_RS07575 (EQH39_07995) 1522684..1523781 - 1098 WP_000156345.1 nucleotidyltransferase -
EQH39_RS07580 (EQH39_08000) 1523791..1524537 - 747 WP_000605154.1 class I SAM-dependent methyltransferase -
EQH39_RS07585 (EQH39_08005) 1524640..1524993 - 354 WP_001003001.1 ribosome silencing factor -
EQH39_RS07590 (EQH39_08010) 1525006..1525506 - 501 WP_000844707.1 cysteine hydrolase family protein -
EQH39_RS07595 (EQH39_08015) 1525507..1526100 - 594 WP_000121654.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
EQH39_RS07600 (EQH39_08020) 1526100..1526729 - 630 WP_000151307.1 nicotinate-nucleotide adenylyltransferase -
EQH39_RS07605 (EQH39_08025) 1526781..1527092 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T117447 WP_000924721.1 NZ_CP035241:c1522188-1521934 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T117447 NZ_CP035241:c1522188-1521934 [Streptococcus pneumoniae]
ATGCTACTCAAGTTTACAGAAGATGCGTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9718.05 Da        Isoelectric Point: 4.8430

>AT117447 WP_000388571.1 NZ_CP035241:c1522446-1522192 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSIQVH
VIEE

Download         Length: 255 bp

>AT117447 NZ_CP035241:c1522446-1522192 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCTCAAAATAAGGAGTTATCAGACAAGGTTTTGCGAGGAATGGCTCAAGTCCGTGCTGGAAGCATTCAGGTCCAT
GTGATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB A0A0B7LSG7

References