117445

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1696487..1697155 Replicon chromosome
Accession NZ_CP035239
Organism Streptococcus pneumoniae strain TVO_TIGR4

Toxin (Protein)


Gene name hicA Uniprot ID A0A0B7M7X4
Locus tag EQH41_RS08375 Protein ID WP_001132284.1
Coordinates 1696976..1697155 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag EQH41_RS08370 Protein ID WP_000961810.1
Coordinates 1696487..1696939 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH41_RS08345 (EQH41_08900) 1692379..1693122 - 744 WP_001188203.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
EQH41_RS08350 (EQH41_08905) 1693124..1694074 - 951 WP_000451153.1 50S ribosomal protein L11 methyltransferase -
EQH41_RS08355 (EQH41_08910) 1694210..1694638 - 429 WP_000418173.1 NUDIX hydrolase -
EQH41_RS08360 (EQH41_08915) 1694619..1695707 - 1089 WP_000719713.1 site-2 protease family protein -
EQH41_RS08365 (EQH41_08920) 1695726..1696196 - 471 WP_000257087.1 DUF3013 family protein -
EQH41_RS08370 (EQH41_08925) 1696487..1696939 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EQH41_RS08375 (EQH41_08930) 1696976..1697155 - 180 WP_001132284.1 type II toxin-antitoxin system HicA family toxin Toxin
EQH41_RS08380 (EQH41_08935) 1697292..1697471 - 180 WP_001048906.1 hypothetical protein -
EQH41_RS08385 (EQH41_08945) 1697636..1697857 - 222 WP_000425689.1 hypothetical protein -
EQH41_RS08390 (EQH41_08950) 1698149..1699420 + 1272 WP_001113214.1 replication-associated recombination protein A -
EQH41_RS08400 (EQH41_08965) 1699977..1701233 - 1257 WP_000436400.1 ISL3 family transposase -
EQH41_RS08405 (EQH41_08970) 1701539..1702114 - 576 WP_000810872.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1699977..1701233 1256


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T117445 WP_001132284.1 NZ_CP035239:c1697155-1696976 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T117445 NZ_CP035239:c1697155-1696976 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT117445 WP_000961810.1 NZ_CP035239:c1696939-1696487 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT117445 NZ_CP035239:c1696939-1696487 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGGCTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7M7X4

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References