Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1574444..1574956 Replicon chromosome
Accession NZ_CP035238
Organism Streptococcus pneumoniae strain TVO_D39

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag EQH42_RS07790 Protein ID WP_000924721.1
Coordinates 1574444..1574698 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag EQH42_RS07795 Protein ID WP_000388572.1
Coordinates 1574702..1574956 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH42_RS07775 (EQH42_08230) 1571545..1571859 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
EQH42_RS07780 (EQH42_08235) 1571884..1572510 - 627 WP_000775044.1 guanylate kinase -
EQH42_RS07785 (EQH42_08240) 1572640..1574253 - 1614 WP_000404940.1 ribonuclease Y -
EQH42_RS07790 (EQH42_08245) 1574444..1574698 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
EQH42_RS07795 (EQH42_08250) 1574702..1574956 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EQH42_RS07800 (EQH42_08255) 1575194..1576291 - 1098 WP_000156355.1 nucleotidyltransferase -
EQH42_RS07805 (EQH42_08260) 1576301..1577047 - 747 WP_000605157.1 class I SAM-dependent methyltransferase -
EQH42_RS07810 (EQH42_08265) 1577150..1577503 - 354 WP_001003001.1 ribosome silencing factor -
EQH42_RS07815 (EQH42_08270) 1577516..1578016 - 501 WP_000844717.1 cysteine hydrolase family protein -
EQH42_RS07820 (EQH42_08275) 1578017..1578610 - 594 WP_000121655.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
EQH42_RS07825 (EQH42_08280) 1578610..1579239 - 630 WP_000151313.1 nicotinate-nucleotide adenylyltransferase -
EQH42_RS07830 (EQH42_08285) 1579291..1579602 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T117439 WP_000924721.1 NZ_CP035238:c1574698-1574444 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T117439 NZ_CP035238:c1574698-1574444 [Streptococcus pneumoniae]
ATGCTACTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT117439 WP_000388572.1 NZ_CP035238:c1574956-1574702 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT117439 NZ_CP035238:c1574956-1574702 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCCCAAAATAAGGAGTTATCAGACAAGGTTTTACGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGGTCCAT
GTGATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References