Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4476346..4476992 Replicon chromosome
Accession NZ_CP035210
Organism Klebsiella pneumoniae strain TH164

Toxin (Protein)


Gene name higB Uniprot ID A0A486RBU5
Locus tag EQH51_RS21870 Protein ID WP_032410616.1
Coordinates 4476346..4476693 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag EQH51_RS21875 Protein ID WP_002920557.1
Coordinates 4476693..4476992 (+) Length 100 a.a.

Genomic Context


EQH51_RS21860EQH51_RS21865EQH51_RS21870EQH51_RS21875EQH51_RS21885EQH51_RS21890EQH51_RS21895EQH51_RS21880
Location: 4472272..4473705 (1434 bp)
Type: Others
Protein ID: WP_002920564.1
Location: 4473723..4476170 (2448 bp)
Type: Others
Protein ID: WP_002920561.1
Location: 4476346..4476693 (348 bp)
Type: Toxin
Protein ID: WP_032410616.1
Location: 4476693..4476992 (300 bp)
Type: Antitoxin
Protein ID: WP_002920557.1
Location: 4478768..4479097 (330 bp)
Type: Others
Protein ID: WP_002920552.1
Location: 4479148..4479978 (831 bp)
Type: Others
Protein ID: WP_004151408.1
Location: 4480028..4480786 (759 bp)
Type: Others
Protein ID: WP_002920548.1
Location: 4477055..4478563 (1509 bp)
Type: Others
Protein ID: WP_002920554.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EQH51_RS218604472272..4473705+1434WP_002920564.1glycogen synthase GlgA-
EQH51_RS218654473723..4476170+2448WP_002920561.1glycogen phosphorylase-
EQH51_RS218704476346..4476693+348WP_032410616.1type II toxin-antitoxin system RelE/ParE family toxinToxin
EQH51_RS218754476693..4476992+300WP_002920557.1helix-turn-helix transcriptional regulatorAntitoxin
EQH51_RS218804477055..4478563-1509WP_002920554.1glycerol-3-phosphate dehydrogenase-
EQH51_RS218854478768..4479097+330WP_002920552.1thiosulfate sulfurtransferase GlpE-
EQH51_RS218904479148..4479978+831WP_004151408.1rhomboid family intramembrane serine protease GlpG-
EQH51_RS218954480028..4480786+759WP_002920548.1DeoR/GlpR family transcriptional regulator-

Associated MGEs


Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-107)

Antitoxin

(9-87)


Sequences


Toxin        


Download         Length: 116 a.a.        Molecular weight: 13545.55 Da        Isoelectric Point: 5.6802

>T117399 WP_032410616.1 NZ_CP035210:4476346-4476693 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATILILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFEPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T117399 NZ_CP035210:4476346-4476693 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATTCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGAGCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT117399 WP_002920557.1 NZ_CP035210:4476693-4476992 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT117399 NZ_CP035210:4476693-4476992 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A486RBU5


Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0E1CBF8

References