Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4677303..4677949 Replicon chromosome
Accession NZ_CP035196
Organism Klebsiella pneumoniae strain LH375

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EP126_RS22825 Protein ID WP_023317328.1
Coordinates 4677303..4677650 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EP126_RS22830 Protein ID WP_032412314.1
Coordinates 4677650..4677949 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EP126_RS22815 4673229..4674662 + 1434 WP_002920564.1 glycogen synthase GlgA -
EP126_RS22820 4674680..4677127 + 2448 WP_002920561.1 glycogen phosphorylase -
EP126_RS22825 4677303..4677650 + 348 WP_023317328.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EP126_RS22830 4677650..4677949 + 300 WP_032412314.1 XRE family transcriptional regulator Antitoxin
EP126_RS22835 4678012..4679520 - 1509 WP_032412313.1 glycerol-3-phosphate dehydrogenase -
EP126_RS22840 4679725..4680054 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
EP126_RS22845 4680105..4680935 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
EP126_RS22850 4680985..4681743 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13562.60 Da        Isoelectric Point: 6.2327

>T117342 WP_023317328.1 NZ_CP035196:4677303-4677650 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
ILCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T117342 NZ_CP035196:4677303-4677650 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
ATTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10828.64 Da        Isoelectric Point: 10.1464

>AT117342 WP_032412314.1 NZ_CP035196:4677650-4677949 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGIKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT117342 NZ_CP035196:4677650-4677949 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGATAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References