Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2550607..2550932 Replicon chromosome
Accession NZ_CP035163
Organism Bacillus subtilis strain SRCM103923

Toxin (Protein)


Gene name txpA Uniprot ID P54373
Locus tag EQI27_RS13240 Protein ID WP_004398662.1
Coordinates 2550607..2550786 (+) Length 60 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2550710..2550932 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQI27_RS13230 2549833..2549970 - 138 WP_021480099.1 hypothetical protein -
EQI27_RS13235 2550012..2550461 - 450 WP_032722171.1 phage portal protein -
EQI27_RS13240 2550607..2550786 + 180 WP_004398662.1 type I toxin-antitoxin system toxin TxpA Toxin
- 2550710..2550932 - 223 NuclAT_0 - Antitoxin
- 2550710..2550932 - 223 NuclAT_0 - Antitoxin
- 2550710..2550932 - 223 NuclAT_0 - Antitoxin
- 2550710..2550932 - 223 NuclAT_0 - Antitoxin
EQI27_RS13245 2551166..2551255 + 90 WP_075058862.1 type I toxin-antitoxin system toxin BsrH -
EQI27_RS13250 2551509..2551952 - 444 WP_003229930.1 phage tail tube protein -
EQI27_RS13255 2551955..2553354 - 1400 Protein_2542 phage tail sheath family protein -
EQI27_RS13260 2553355..2553546 - 192 WP_010886574.1 hypothetical protein -
EQI27_RS13265 2553543..2553980 - 438 WP_003229927.1 hypothetical protein -
EQI27_RS13270 2553993..2554496 - 504 WP_003246050.1 HK97 gp10 family phage protein -
EQI27_RS13275 2554493..2554855 - 363 WP_003229925.1 YqbH/XkdH family protein -
EQI27_RS13280 2554852..2555247 - 396 WP_004398566.1 DUF3199 family protein -
EQI27_RS13285 2555251..2555562 - 312 WP_003229923.1 YqbF domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2525359..2575481 50122


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.



Sequences


Toxin        


Download         Length: 60 a.a.        Molecular weight: 6739.19 Da        Isoelectric Point: 8.0370

>T117260 WP_004398662.1 NZ_CP035163:2550607-2550786 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Download         Length: 180 bp

>T117260 NZ_CP035163:2550607-2550786 [Bacillus subtilis]
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG

Antitoxin


Download         Length: 223 bp

>AT117260 NZ_CP035163:c2550932-2550710 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A164X333


Antitoxin

Download structure file

References