117204

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 626726..627951 Replicon chromosome
Accession NZ_CP035108
Organism Geovibrio thiophilus strain DSM 11263

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag EP073_RS03030 Protein ID WP_128465694.1
Coordinates 626726..627646 (-) Length 307 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag EP073_RS03035 Protein ID WP_128465695.1
Coordinates 627643..627951 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EP073_RS03010 623761..623931 + 171 WP_128465692.1 hypothetical protein -
EP073_RS03015 623928..624617 + 690 WP_128465693.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
EP073_RS13805 624690..624866 + 177 WP_164885222.1 hypothetical protein -
EP073_RS03020 624866..626488 + 1623 WP_206617493.1 sodium/solute symporter -
EP073_RS03030 626726..627646 - 921 WP_128465694.1 HipA domain-containing protein Toxin
EP073_RS03035 627643..627951 - 309 WP_128465695.1 HipA N-terminal domain-containing protein Antitoxin
EP073_RS03040 627944..628153 - 210 WP_128465696.1 helix-turn-helix transcriptional regulator -
EP073_RS03045 628486..629763 - 1278 WP_128465697.1 ATP-binding protein -
EP073_RS03050 629861..630610 - 750 WP_128465698.1 CoA activase -
EP073_RS03055 630600..631598 - 999 WP_128465699.1 2-hydroxyacyl-CoA dehydratase -
EP073_RS03060 631595..631882 - 288 WP_128465700.1 hypothetical protein -
EP073_RS03065 631977..632273 - 297 WP_128465701.1 succinate dehydrogenase assembly factor 2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(50-275)

Antitoxin

HipA, N-terminal subdomain 1

(4-97)


Sequences

Toxin        


Download         Length: 307 a.a.        Molecular weight: 34785.17 Da        Isoelectric Point: 9.6341

>T117204 WP_128465694.1 NZ_CP035108:c627646-626726 [Geovibrio thiophilus]
MRCPVTYEETNYRYSEAGLKIINRSLKELHELPYTKDELRIEAAARSEKMSIQGVQPKLPARLNVKGGVFELTNGGGQYI
LKPQSADYPELPENEDLTMRLAKSYGLDVPLHFMIYGKDGALTYVIKRFDRAGKNRKLSVEDFAQLSGATRDTKYRSSME
QVAKIIEKYCTFPQIEKEKLFKLTLFSFITGNEDMHLKNFSLIYEGGKVQLSPVYDLLNTTAAVPNPIEELALPLNAKKN
RITKADLADYYGKERLGLNEKVIDKALSSLESVSAGWGKTIEKSFLSAGMKEKYLKLLTERRKRLF

Download         Length: 921 bp

>T117204 NZ_CP035108:c627646-626726 [Geovibrio thiophilus]
ATGAGGTGCCCGGTTACCTATGAAGAGACTAATTACAGATACAGTGAAGCGGGTTTGAAAATCATTAACCGTAGCCTGAA
AGAACTGCATGAACTGCCTTACACGAAAGACGAGCTCCGCATTGAGGCAGCGGCTAGGTCTGAAAAGATGTCTATCCAAG
GCGTTCAGCCGAAGCTGCCCGCAAGGCTGAATGTCAAGGGAGGCGTTTTTGAGCTTACGAACGGGGGCGGGCAGTATATT
CTAAAGCCGCAGTCTGCCGATTACCCTGAACTGCCCGAAAATGAAGACCTGACAATGCGGCTTGCGAAATCTTACGGACT
GGATGTGCCGCTCCATTTCATGATTTACGGTAAAGACGGCGCACTCACATATGTAATTAAGCGTTTTGACCGTGCGGGAA
AAAACAGGAAACTGTCTGTTGAGGATTTTGCCCAGCTGTCCGGAGCGACACGGGATACCAAGTACCGCTCCAGCATGGAG
CAGGTGGCGAAAATAATAGAAAAATACTGCACTTTCCCGCAAATAGAAAAAGAGAAGCTTTTTAAGCTGACCCTGTTTTC
GTTTATCACAGGAAACGAGGATATGCACCTGAAAAACTTCTCTCTGATATATGAGGGCGGTAAAGTTCAGCTTTCACCTG
TTTATGATCTCCTCAACACAACTGCTGCTGTTCCCAACCCCATAGAAGAGCTTGCATTGCCGCTTAATGCCAAAAAGAAC
AGAATAACCAAAGCCGACCTTGCGGATTATTACGGGAAAGAAAGGCTTGGTCTGAATGAGAAGGTGATTGATAAAGCGCT
GTCATCACTTGAATCTGTTTCTGCGGGCTGGGGCAAGACAATTGAGAAAAGCTTTCTTTCCGCAGGCATGAAGGAAAAAT
ATTTAAAACTGCTCACGGAACGCCGGAAAAGATTATTTTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11351.88 Da        Isoelectric Point: 4.1964

>AT117204 WP_128465695.1 NZ_CP035108:c627951-627643 [Geovibrio thiophilus]
MRKALVYQQGIPAGFLTETERGYEFQYLPDYDGTAVSLTLPVAGKPYQFDDFPPFFDGLLPEGYLLESLLRRLKIDRNDS
FSQLIAVGADLVGSVTVKEAAE

Download         Length: 309 bp

>AT117204 NZ_CP035108:c627951-627643 [Geovibrio thiophilus]
ATGCGTAAGGCGCTTGTATACCAACAGGGGATACCTGCCGGATTTCTCACTGAGACTGAACGCGGGTACGAATTCCAATA
TCTTCCGGATTATGACGGCACAGCAGTTTCACTCACACTTCCTGTAGCAGGCAAACCCTATCAGTTTGATGATTTTCCGC
CTTTTTTCGACGGACTTCTGCCGGAGGGTTATCTGCTTGAATCACTGCTGAGAAGGCTCAAGATCGACCGCAACGATTCT
TTTTCACAATTAATCGCTGTGGGGGCTGATCTTGTCGGTTCTGTCACTGTGAAAGAGGCGGCGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References