117200

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2468000..2468523 Replicon chromosome
Accession NZ_CP035101
Organism Staphylococcus aureus strain ATCC 12600

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag EQG65_RS12535 Protein ID WP_000074048.1
Coordinates 2468000..2468266 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag EQG65_RS12540 Protein ID WP_000587616.1
Coordinates 2468266..2468523 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQG65_RS12515 2463307..2464494 - 1188 WP_000026194.1 MFS transporter -
EQG65_RS12520 2464890..2465666 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
EQG65_RS12525 2465659..2466321 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
EQG65_RS12530 2466569..2467645 - 1077 WP_001076671.1 M42 family metallopeptidase -
EQG65_RS12535 2468000..2468266 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
EQG65_RS12540 2468266..2468523 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EQG65_RS12545 2468629..2468823 - 195 WP_001790145.1 hypothetical protein -
EQG65_RS12550 2468882..2469337 + 456 WP_000732082.1 DUF1307 domain-containing protein -
EQG65_RS12555 2469505..2471082 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
EQG65_RS12560 2471277..2472026 + 750 WP_000072443.1 hypothetical protein -
EQG65_RS12565 2472250..2473443 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T117200 WP_000074048.1 NZ_CP035101:c2468266-2468000 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T117200 NZ_CP035101:c2468266-2468000 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT117200 WP_000587616.1 NZ_CP035101:c2468523-2468266 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT117200 NZ_CP035101:c2468523-2468266 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References