Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2436499..2436683 Replicon chromosome
Accession NZ_CP035101
Organism Staphylococcus aureus strain ATCC 12600

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag EQG65_RS12395 Protein ID WP_000482650.1
Coordinates 2436576..2436683 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2436499..2436559 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQG65_RS12380 2432029..2432196 - 168 WP_001790576.1 hypothetical protein -
EQG65_RS12385 2432427..2434160 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
EQG65_RS12390 2434185..2435948 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 2436499..2436559 + 61 - - Antitoxin
EQG65_RS12395 2436576..2436683 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
EQG65_RS12400 2436817..2437203 - 387 WP_000779358.1 flippase GtxA -
EQG65_RS12405 2437471..2438613 + 1143 WP_001176863.1 glycerate kinase -
EQG65_RS12410 2438673..2439332 + 660 WP_000831298.1 membrane protein -
EQG65_RS12415 2439514..2440725 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
EQG65_RS12420 2440848..2441321 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T117198 WP_000482650.1 NZ_CP035101:c2436683-2436576 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T117198 NZ_CP035101:c2436683-2436576 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT117198 NZ_CP035101:2436499-2436559 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References